Promises and challenges of immunogenic chemotherapy in multiple myeloma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F22%3AE0109747" target="_blank" >RIV/00843989:_____/22:E0109747 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/22:A2302J5B
Result on the web
<a href="https://www.mdpi.com/2073-4409/11/16/2519" target="_blank" >https://www.mdpi.com/2073-4409/11/16/2519</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cells11162519" target="_blank" >10.3390/cells11162519</a>
Alternative languages
Result language
angličtina
Original language name
Promises and challenges of immunogenic chemotherapy in multiple myeloma
Original language description
Immunological tolerance of myeloma cells represents a critical obstacle in achieving long-term disease-free survival for multiple myeloma (MM) patients. Over the past two decades, remarkable preclinical efforts to understand MM biology have led to the clinical approval of several targeted and immunotherapeutic agents. Among them, it is now clear that chemotherapy can also make cancer cells "visible" to the immune system and thus reactivate anti-tumor immunity. This knowledge represents an important resource in the treatment paradigm of MM, whereas immune dysfunction constitutes a clear obstacle to the cure of the disease. In this review, we highlight the importance of defining the immunological effects of chemotherapy in MM with the goal of enhancing the clinical management of patients. This area of investigation will open new avenues of research to identify novel immunogenic anti-MM agents and inform the optimal integration of chemotherapy with immunotherapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cells
ISSN
2073-4409
e-ISSN
2073-4409
Volume of the periodical
11
Issue of the periodical within the volume
article 2519
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
1-15
UT code for WoS article
000846956900001
EID of the result in the Scopus database
2-s2.0-85136615614