Amniotic fluid soluble CD93 is elevated in the presence of intra-amniotic inflammation in preterm prelabor rupture of the fetal membranes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F22%3AE0110010" target="_blank" >RIV/00843989:_____/22:E0110010 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/22:A2302I4Y

Result on the web

<a href="https://www.cs-gynekologie.cz/casopisy/ceska-gynekologie/2022-6-6/intra-amnialni-zanet-u-predcasneho-odtoku-plodove-vody-pred-terminem-porodu-je-spojen-se-zvysenim-hladin-scd93-v-plodove-vode-133023?hl=en" target="_blank" >https://www.cs-gynekologie.cz/casopisy/ceska-gynekologie/2022-6-6/intra-amnialni-zanet-u-predcasneho-odtoku-plodove-vody-pred-terminem-porodu-je-spojen-se-zvysenim-hladin-scd93-v-plodove-vode-133023?hl=en</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.48095/cccg2022388" target="_blank" >10.48095/cccg2022388</a>

Result language

angličtina

Original language name

Amniotic fluid soluble CD93 is elevated in the presence of intra-amniotic inflammation in preterm prelabor rupture of the fetal membranes

Original language description

Objective: To determine the soluble form of CD93 (sCD93) concentration in amniotic fluid from pregnancies complicated by preterm prelabor rupture of membranes (PPROM) based on the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation. Methods: A total of 144 women with a singleton pregnancy complicated by PPROM were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis. MIAC was determined by the combination of cultivation and non-cultivation techniques. Intra-amniotic inflammation was characterized as a concentration of interleukin-6 ? 3,000 pg/mL in amniotic fluid. Women were categorized in the following groups: i) intra-amniotic infection (both MIAC and intra-amniotic inflammation), ii) sterile intra-amniotic inflammation (intra-amniotic inflammation per se), iii) colonization of the amniotic cavity (MIAC per se), and iv) negative amniotic fluid (without both MIAC and intra-amniotic inflammation). Levels of sCD93 in amniotic fluid were assessed by ELISA. Results: A difference in the levels of sCD93 in amniotic fluid was found among the groups of women with intra-amniotic infection, sterile intra-amniotic inflammation, colonization of the amniotic cavity, and negative amniotic fluid (intra-amniotic infection: median 22.3 ng/mL, sterile intra-amniotic inflammation: median 21.0 ng/mL, colonization of the amniotic cavity: 8.7 ng/mL, negative: median 8.7 ng/mL; P < 0.0001). Conclusions: Intra-amniotic inflammation in PPROM, irrespectively of the presence or absence of MIAC, is associated with the elevation of the level of sCD93 in amniotic fluid.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30214 - Obstetrics and gynaecology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká gynekologie

ISSN

1210-7832

e-ISSN

1805-4455

Volume of the periodical

87

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

388-395

UT code for WoS article

999

EID of the result in the Scopus database

2-s2.0-85144392556