Comparison of MwPharm 3.30 and MwPharm ++ a Windows version of pharmacokinetic software for PK/PD monitoring of vancomycin: A priori modeling

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F22%3AE0110072" target="_blank" >RIV/00843989:_____/22:E0110072 - isvavai.cz</a>

Result on the web

<a href="https://www.dustri.com/article_response_page.html?artId=189417&doi=10.5414/CP204151&L=0" target="_blank" >https://www.dustri.com/article_response_page.html?artId=189417&doi=10.5414/CP204151&L=0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5414/CP204151" target="_blank" >10.5414/CP204151</a>

Result language

angličtina

Original language name

Comparison of MwPharm 3.30 and MwPharm ++ a Windows version of pharmacokinetic software for PK/PD monitoring of vancomycin: A priori modeling

Original language description

Objective: To evaluate the possibility of population-based dose optimization with the aid of MwPharm modeling and to find the best model in the Windows version (WIN). Materials: 25 patients repeatedly examined for vancomycin (mean age 63 ± 14 years, body weight 88 ± 21 kg, median dose 1 g/12 h). Methods: Trough concentrations predicted by WIN models "vancomycin_adult_k_C2", "#vancomycin_adult_C2", "vancomycin_adult_C2", and "vancomycin adult" DOS model (DOS) were compared with the measured value. Statistics: The percentage prediction error (%PE) calculated as (predicted - measured)/measured values, Blandt-Altman plot, root mean square error (RMSE), Pearson's coefficient of rank correlation (R). Data is presented as mean ± SD. Student's t-test was used for prediction precision evaluation. Results: The %PE varied from +44.4 ± 65.2% to +76.5 ± 84.3%, p < 0.001. "#vancomycin_adult_C2" model produced the lowest %PE among WIN models as well as the lowest RMSE (79) and Blandt-Altman bias (-4.01 ± 7.59), but the Pearson's correlation (0.6843, p = 0.0002) was less tight. DOS model produced the second lowest RMSE (81), %PE (+45.9 ± 66.6%), and Blandt-Altman bias (-4.83 ± 6.97) and highest Pearson's R (0.7847, p < 0.0001). "vancomycin_adult_C2" produced the third best prediction: RMSE (113), %PE (62.8 ± 92.6%), Blandt-Altman bias (-6.78 ± 11.2) but Pearson's R was the poorest (0.5773, p = 0.0025). Conclusion: The lowest %PE and highest Pearson's R were achieved by the "#vancomycin_adult_C2" model. Due to the poor predictive performance of all MwPharm versions and models, we find all of them unsuitable for a priori vancomycin dosing management. Other software should be evaluated for routine use.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International journal of clinical pharmacology and therapeutics

ISSN

0946-1965

e-ISSN

0946-1965

Volume of the periodical

60

Issue of the periodical within the volume

7

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

299-305

UT code for WoS article

000817739500002

EID of the result in the Scopus database

2-s2.0-85133102646