Influence of opioid analgesia type on circulating tumor cells in open colorectal cancer surgery (POACC-1): study protocol for a prospective randomized multicenter controlled trial
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F23%3AE0110175" target="_blank" >RIV/00843989:_____/23:E0110175 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/23:00133351 RIV/61988987:17110/23:A2402NNQ RIV/00216208:11110/23:10464302 RIV/00098892:_____/23:10157970 and 2 more
Result on the web
<a href="https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-023-02007-1" target="_blank" >https://bmcanesthesiol.biomedcentral.com/articles/10.1186/s12871-023-02007-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12871-023-02007-1" target="_blank" >10.1186/s12871-023-02007-1</a>
Alternative languages
Result language
angličtina
Original language name
Influence of opioid analgesia type on circulating tumor cells in open colorectal cancer surgery (POACC-1): study protocol for a prospective randomized multicenter controlled trial
Original language description
Background: Opioids and epidural analgesia are a mainstay of perioperative analgesia but their influence on cancer recurrence remains unclear. Based on retrospective data, we found that cancer recurrence following colorectal cancer surgery correlates with the number of circulating tumor cells (CTCs) in the early postoperative period. Also, morphine- but not piritramide-based postoperative analgesia increases the presence of CTCs and shortens cancer-specific survival. The influence of epidural analgesia on CTCs has not been studied yet. Methods: We intend to enroll 120 patients in four centers in this prospective randomized controlled trial. The study protocol has been approved by Ethics Committees in all participating centers. Patients undergoing radical open colorectal cancer surgery are randomized into epidural, morphine, and piritramide groups for perioperative analgesia. The primary outcome is the difference in the number of CTCs in the peripheral blood before surgery, on the second postoperative day, and 2-4 weeks after surgery. The number of CTCs is measured using molecular biology methods. Perioperative care is standardized, and relevant data is recorded. A secondary outcome, if feasible, would be the expression and activity of various receptor subtypes in cancer tissue. We intend to perform a 5-year follow-up with regard to metastasis development. Discussion: The mode of perioperative analgesia favorably affecting cancer recurrence would decrease morbidity/mortality. To identify such techniques, trials with long-term follow-up periods seem suboptimal. Given complex oncological therapeutic strategies, such trials likely disable the separation of perioperative analgesia effects from other factors. We believe that early postoperative CTCs presence/dynamics may serve as a sensitive marker of various perioperative interventions ´ influences on cancer recurrence. Importantly, it is unbiased to the influence of long-term factors and minimally invasive. Analysis ...
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30221 - Critical care medicine and Emergency medicine
Result continuities
Project
<a href="/en/project/NV18-03-00470" target="_blank" >NV18-03-00470: Effects of perioperative opioid analgesia on circulating tumor cells in colorectal cancer: multicenter randomized clinical trial</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC Anesthesiology
ISSN
1471-2253
e-ISSN
—
Volume of the periodical
23
Issue of the periodical within the volume
article 64
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
1-9
UT code for WoS article
000940159000002
EID of the result in the Scopus database
2-s2.0-85149022109