HPV and RAD51 as prognostic factors for survival in inoperable oral and oropharyngeal cancer in patients unfit for chemotherapy treated with hyperfractionated radiotherapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F23%3AE0110191" target="_blank" >RIV/00843989:_____/23:E0110191 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/23:00130670 RIV/61988987:17110/23:A2402NGY RIV/00216208:11120/23:43925158 RIV/61989592:15110/23:73621293 and 2 more
Result on the web
<a href="https://www.mdpi.com/1648-9144/59/2/361" target="_blank" >https://www.mdpi.com/1648-9144/59/2/361</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/medicina59020361" target="_blank" >10.3390/medicina59020361</a>
Alternative languages
Result language
angličtina
Original language name
HPV and RAD51 as prognostic factors for survival in inoperable oral and oropharyngeal cancer in patients unfit for chemotherapy treated with hyperfractionated radiotherapy
Original language description
Introduction: The incidence of advanced oral cavity and oropharyngeal cancers is generally high. Treatment outcomes for patients, especially those unfit for comprehensive cancer treatment, are unsatisfactory. Therefore, the search for factors to predict response to treatment and increase overall survival is underway. Objective: This study aimed to analyze the presence of 32 HPV genotypes in tumor samples of 34 patients and the effect of HPV status and RAD51 on overall survival. Method: Tumor samples of 34 patients with locally advanced oropharyngeal or oral cavity cancer treated with accelerated radiotherapy in monotherapy were analyzed using reverse hybridization and immunohistochemistry for the presence of HPV and RAD51. Its effect on overall survival was examined. Results: Only two types of HPV were identified-HPV 16 (dominant) and HPV 66 (two samples). The HPV positivity was associated with a borderline insignificant improvement in 2-year (p = 0.083), 5-year (p = 0.159), and overall survival (p = 0.083). Similarly, the RAD51 overexpression was associated with borderline insignificant improvement in 2-year (p = 0.083) and 5-year (p = 0.159) survival. Conclusion: We found no statistically significant differences but detected trends toward improvement in the survival of HPV-positive and RAD51 overexpressing patients unfit for surgical treatment or chemotherapy treated with hyperfractionated radiotherapy. The trends, however, indicate that in a larger group of patients, the effects of these two parameters would likely be statistically significant.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medicina
ISSN
1010-660X
e-ISSN
1648-9144
Volume of the periodical
59
Issue of the periodical within the volume
article 361
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
1-12
UT code for WoS article
000939961000001
EID of the result in the Scopus database
2-s2.0-85148910954