Celiac disease: Promising biomarkers for follow-up

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F23%3AE0110583" target="_blank" >RIV/00843989:_____/23:E0110583 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/23:00132727 RIV/61988987:17110/23:A2402NYA RIV/61989592:15110/23:73621821 RIV/65269705:_____/23:00078874 and 2 more

Result on the web

<a href="https://jgld.ro/jgld/index.php/jgld/article/view/4926/1999" target="_blank" >https://jgld.ro/jgld/index.php/jgld/article/view/4926/1999</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.15403/jgld-4926" target="_blank" >10.15403/jgld-4926</a>

Result language

angličtina

Original language name

Celiac disease: Promising biomarkers for follow-up

Original language description

Celiac disease is a common gastroenterological illness. Current diagnostics of the disease are based on serological markers and histology of duodenal biopsies. Hitherto, a strict gluten-free diet is the only effective treatment and is necessary for good control of the disease. Serological tests in current use have very high specificity and sensitivity for diagnostics, but in follow-up they have some limitations. Their levels do not accurately reflect mucosal healing, and they are unable to detect minimal transgressions in the diet. This problem is significant in patients with IgA deficiency, and there exist no robust follow-up tools for monitoring these patients' adherence to treatment. For their follow-up, we currently use IgG-based tests, and these antibodies persist for a long time even when a patient has stopped consuming gluten. More accurate and specific biomarkers are definitely needed. Adherence to a gluten-free diet is essential not only for intestinal mucosa healing and alleviation of symptoms but also for preventing complications associated with celiac disease. Here, we summarize current evidence regarding noninvasive biomarkers potentially useful for follow-up not only of patients with IgA deficiency but for all patients with celiac disease. We describe several very promising biomarkers with potential to be part of clinical practice in the near future.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30219 - Gastroenterology and hepatology

Project

<a href="/en/project/NU23-06-00553" target="_blank" >NU23-06-00553: Optimization of celiac disease monitoring and new possibilities of its prevention</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of gastrointestinal and liver diseases

ISSN

1841-8724

e-ISSN

1842-1121

Volume of the periodical

32

Issue of the periodical within the volume

4

Country of publishing house

RO - ROMANIA

Number of pages

9

Pages from-to

536-544

UT code for WoS article

001158173500017

EID of the result in the Scopus database

2-s2.0-85180874390