Therapeutic monitoring of lacosamide, perampanel, and zonisamide during breastfeeding

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F24%3AE0110591" target="_blank" >RIV/00843989:_____/24:E0110591 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/24:A2502NYT

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0920121123001894?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0920121123001894?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.eplepsyres.2023.107264" target="_blank" >10.1016/j.eplepsyres.2023.107264</a>

Result language

angličtina

Original language name

Therapeutic monitoring of lacosamide, perampanel, and zonisamide during breastfeeding

Original language description

Objective: To provide additional information on the transport of the new anti-seizure medications lacosamide, perampanel, and zonisamide in breast milk and breastfed infants. Methods: Between 2013 and 2022, concentrations of anti-seizure medications were measured in six women with epilepsy (each drug in two patients) using high-performance liquid chromatography. Additionally, concentrations were determined after two consecutive pregnancies in women receiving lacosamide and one woman receiving zonisamide. In all cases, anti-seizure medication concentrations were measured in the maternal serum and breast milk, and five cases, in the infant serum. Results: For lacosamide, the ratios of breast milk/maternal serum concentration varied between 0.77 and 0.93, the ratios of infant/maternal serum concentrations were 0.16 and 0.35, and the ratios of infant serum/milk concentrations were 0.21 and 0.38. For perampanel, the ratios of breast milk/maternal serum concentration were 0.01 and 0.10 and the ratio of infant/maternal serum concentration was 0.36. For zonisamide, the ratios of breast milk/maternal serum concentration varied between 0.76 and 1.26, the ratios of infant/maternal serum concentrations between 0.44 and 0.85, and the ratios of infant serum/milk concentrations between 0.55 and 1.05. Conclusions: Breastfeeding is recommended for women using lacosamide, perampanel, and zonisamide. However, the actual exposure can only be accurately evaluated by determining the serum concentration of anti-seizure medication in breastfed infants.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Epilepsy Research

ISSN

0920-1211

e-ISSN

1872-6844

Volume of the periodical

199

Issue of the periodical within the volume

january

Country of publishing house

NZ - NEW ZEALAND

Number of pages

5

Pages from-to

1-5

UT code for WoS article

001133520200001

EID of the result in the Scopus database

2-s2.0-85179104694