Potential diagnostic and clinical significance of selected genetic alterations in glioblastoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F24%3AE0110941" target="_blank" >RIV/00843989:_____/24:E0110941 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/24:A2502O6K
Result on the web
<a href="https://www.mdpi.com/1422-0067/25/8/4438" target="_blank" >https://www.mdpi.com/1422-0067/25/8/4438</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms25084438" target="_blank" >10.3390/ijms25084438</a>
Alternative languages
Result language
angličtina
Original language name
Potential diagnostic and clinical significance of selected genetic alterations in glioblastoma
Original language description
Glioblastoma is currently considered the most common and, unfortunately, also the most aggressive primary brain tumor, with the highest morbidity and mortality rates. The average survival of patients diagnosed with glioblastoma is 14 months, and only 2% of patients survive 3 years after surgery. Based on our clinical experience and knowledge from extensive clinical studies, survival is mainly related to the molecular biological properties of glioblastoma, which are of interest to the general medical community. Our study examined a total of 71 retrospective studies published from 2016 through 2022 and available on PubMed that deal with mutations of selected genes in the pathophysiology of GBM. In conclusion, we can find other mutations within a given gene group that have different effects on the prognosis and quality of survival of a patient with glioblastoma. These mutations, together with the associated mutations of other genes, as well as intratumoral heterogeneity itself, offer enormous potential for further clinical research and possible application in therapeutic practice.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International journal of molecular sciences
ISSN
1422-0067
e-ISSN
1422-0067
Volume of the periodical
25
Issue of the periodical within the volume
article 4438
Country of publishing house
CH - SWITZERLAND
Number of pages
19
Pages from-to
1-19
UT code for WoS article
001210556200001
EID of the result in the Scopus database
2-s2.0-85191623655