Impact of T cell characteristics on CAR-T cell therapy in hematological malignancies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F24%3AE0111248" target="_blank" >RIV/00843989:_____/24:E0111248 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/24:A25039N9
Result on the web
<a href="https://www.nature.com/articles/s41408-024-01193-6" target="_blank" >https://www.nature.com/articles/s41408-024-01193-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41408-024-01193-6" target="_blank" >10.1038/s41408-024-01193-6</a>
Alternative languages
Result language
angličtina
Original language name
Impact of T cell characteristics on CAR-T cell therapy in hematological malignancies
Original language description
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment paradigms for hematological malignancies. However, more than half of these patients cannot achieve sustainable tumor control, partially due to the inadequate potency of CAR-T cells in eradicating tumor cells. T cells are crucial components of the anti-tumor immune response, and multiple intrinsic T-cell features significantly influence the outcomes of CAR-T cell therapy. Herein, we review progressing research on T-cell characteristics that impact the effectiveness of CAR-T cells, including T-cell exhaustion, memory subsets, senescence, regulatory T-cells, the CD4+ to CD8+ T-cell ratio, metabolism, and the T-cell receptor repertoire. With comprehensive insight into the biological processes underlying successful CAR-T cell therapy, we will further refine the applications of these novel therapeutic modalities, and enhance their efficacy and safety for patients.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/EH22_008%2F0004644" target="_blank" >EH22_008/0004644: Saving lives through research in early cancer detection and prevention: Molecular, genomic and societal factors</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Blood cancer journal
ISSN
2044-5385
e-ISSN
2044-5385
Volume of the periodical
14
Issue of the periodical within the volume
article 213
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1-10
UT code for WoS article
001369348500001
EID of the result in the Scopus database
2-s2.0-85211163105