Methylation status of selected genes in non-small cell lung carcinoma - current knowledge and future perspectives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F24%3AE0111392" target="_blank" >RIV/00843989:_____/24:E0111392 - isvavai.cz</a>
Result on the web
<a href="https://www.elis.sk/download_file.php?product_id=8468&session_id=dr9tkumd77kaq3d70jiq61bqf5" target="_blank" >https://www.elis.sk/download_file.php?product_id=8468&session_id=dr9tkumd77kaq3d70jiq61bqf5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2024_240925N403" target="_blank" >10.4149/neo_2024_240925N403</a>
Alternative languages
Result language
angličtina
Original language name
Methylation status of selected genes in non-small cell lung carcinoma - current knowledge and future perspectives
Original language description
DNA methylation is recognized as an early event in cancer initiation and progression. This review aimed to compare the methylation status of promoter regions in selected genes across different histological subtypes of non-small cell lung cancer (NSCLC), including adenocarcinoma, squamous cell carcinoma, large cell carcinoma, and the rare but highly aggressive large-cell neuroendocrine carcinoma (LCNEC). A comprehensive literature search was conducted in the PubMed database until August 17, 2024, using standardized keywords to identify reports on promoter methylation in NSCLC. Seventy-five studies were reviewed, focusing on the promoter methylation of key genes, such as APC, BRCA1, CDH1, CDH13, DAPK1, DLEC1, FHIT, GSTP1, hMLH1, MGMT, CDKN2A, RARß, RASSF1, RUNX3, and TIMP3. These studies explored diagnostic, prognostic, epidemiological, and therapeutic aspects across NSCLC subtypes. Additionally, mutational profiles of TP53, RB1, KEAP1, and STK11 and expression patterns of ASCL1, DLL3, and NOTCH were analyzed. The findings suggest that LCNEC may serve as a biological bridge between non-small cell and small-cell lung carcinoma. Our analysis highlights that the methylation status of selected genes could enhance diagnosis, prognosis, and personalized treatment strategies in patients with NSCLC, particularly those with LCNEC.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neoplasma
ISSN
0028-2685
e-ISSN
1338-4317
Volume of the periodical
71
Issue of the periodical within the volume
6
Country of publishing house
SK - SLOVAKIA
Number of pages
22
Pages from-to
511-532
UT code for WoS article
001416040400001
EID of the result in the Scopus database
2-s2.0-85216439272