Home-based peroneal electrical transcutaneous NeuroModulation (peroneal eTNM®) in Parkinson’s disease as "add-on" treatment -results of a pilot study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F25%3AE0111713" target="_blank" >RIV/00843989:_____/25:E0111713 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/25:A2603DNK RIV/61989100:27360/25:10258313

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2590112525000258?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2590112525000258?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.prdoa.2025.100321" target="_blank" >10.1016/j.prdoa.2025.100321</a>

Result language

angličtina

Original language name

Home-based peroneal electrical transcutaneous NeuroModulation (peroneal eTNM®) in Parkinson’s disease as "add-on" treatment -results of a pilot study

Original language description

Introduction: Currently, there is no causal cure for Parkinson's disease (PD), and medications and other therapeutic procedures only allow for the reduction of symptoms. Noninvasive neuromodulation is among the potentially promising treatments for PD patients. The present pilot study aimed to evaluate the safety and efficacy of peroneal electrical Transcutaneous NeuroModulation (peroneal eTNM®) in the treatment of PD symptoms with a particular emphasis on disease-related quality of life. Methods: Twelve patients with clinically established Parkinsońs disease (8 males; mean age 59.5 ± 11.6 years) were enrolled. In addition to state-of-the-art background pharmacotherapy for PD, patients were treated with peroneal eTNM® daily for 30 min for 6 weeks followed by 6 weeks of follow-up without stimulation. The primary endpoint was safety and tolerability, the secondary endpoint was the response of the condition on the 'add-on' peroneal eTNM®. Results: Peroneal eTNM® proved to be feasible for home treatment in the PD population. Treatment-related adverse events were not reported throughout the study. Along with an excellent safety profile, peroneal eTNM® showed considerable positive trends in terms of improvement in quality of life as measured by EQ-5D-5L questionnaire. There was a definitive trend toward a reduction in Section III of the Unified Parkinson's Disease Rating Scale showing positive changes in tremor-related items. At the end of the study, 50 % of the patients were considered clinical responders. Conclusions: Larger and more rigorously designed studies are needed to validate the utility and position of peroneal eTNM® in the treatment of patients with PD.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical parkinsonism & related disorders

ISSN

2590-1125

e-ISSN

2590-1125

Volume of the periodical

12

Issue of the periodical within the volume

article 100321

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

1-5

UT code for WoS article

001470913300001

EID of the result in the Scopus database

2-s2.0-105002293682