The mechanism of action of neuromodulation in the treatment of overactive bladder

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F25%3AE0111802" target="_blank" >RIV/00843989:_____/25:E0111802 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/25:A2603DQ4

Result on the web

<a href="https://doi.org/10.1038/s41585-024-00967-8" target="_blank" >https://doi.org/10.1038/s41585-024-00967-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41585-024-00967-8" target="_blank" >10.1038/s41585-024-00967-8</a>

Result language

angličtina

Original language name

The mechanism of action of neuromodulation in the treatment of overactive bladder

Original language description

Neuromodulation has been used in the treatment of various pelvic organ dysfunctions for almost 40 years and several placebo-controlled studies have confirmed its clinical effect. Many neuromodulation methods using different devices and stimulation parameters, targeting different neural structures have been introduced, but only a limited number have been adopted into routine clinical use. A substantial volume of basic research and clinical studies addressing specific effects of neuromodulation in the treatment of overactive bladder (OAB) have been published to date; however, their mechanistic implications have not been comprehensively summarized. Thus, our understanding of the mechanism of action of neuromodulation in OAB treatment is mainly based on postulated theories. Results from animal experiments suggest that different neuromodulation methods used to treat OAB share the same basic principles. The most likely explanation for the effect of neuromodulation in OAB therapy is the suppression of bladder afferent signalling, promotion of spinal guarding reflexes and modulation of non-specific supraspinal regulatory circuits.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30217 - Urology and nephrology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature reviews urology

ISSN

1759-4812

e-ISSN

1759-4820

Volume of the periodical

22

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

414-426

UT code for WoS article

001372723400001

EID of the result in the Scopus database

2-s2.0-85211905329