Monitoring treatment response in rectal cancer through circulating tumor cell dynamics: a pilot clinical study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F25%3AE0111935" target="_blank" >RIV/00843989:_____/25:E0111935 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/25:73631678
Result on the web
<a href="https://doi.org/10.1002/jso.70073" target="_blank" >https://doi.org/10.1002/jso.70073</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jso.70073" target="_blank" >10.1002/jso.70073</a>
Alternative languages
Result language
angličtina
Original language name
Monitoring treatment response in rectal cancer through circulating tumor cell dynamics: a pilot clinical study
Original language description
Background: Circulating tumor cells (CTCs) are increasingly recognized as a minimally invasive biomarker with significant potential in oncologic monitoring and prognostication. This study aimed to assess the dynamics of CTC levels in patients with rectal cancer undergoing multimodal treatment and evaluate their potential role in therapeutic decision-making. Methods: We conducted a prospective, observational study of 56 patients with histologically confirmed rectal adenocarcinoma. Patients underwent either primary surgical resection or neoadjuvant chemoradiotherapy (CRT) followed by surgery. Peripheral blood samples were collected at defined intervals and analyzed using the CytoTrack CT11TM system to detect and quantify CTCs. Results: Pretreatment CTCs were detected in 16.1% of patients. In the primary surgery group, all preoperatively positive CTC cases became negative postoperatively, although transient positivity was observed in two cases at 1 week post-surgery. In the CRT group, 35.7% of patients exhibited detectable CTCs during treatment, with complete clearance after surgery. The dynamic change in CTC levels correlated with therapeutic response and potential recurrence risk. Conclusions: This pilot study highlights the clinical relevance of CTC monitoring in rectal cancer. CTC dynamics appear to reflect treatment efficacy and may serve as an early indicator of response. These findings support the development of a randomized clinical trial comparing rectal cancer treatments with and without neoadjuvant therapy, using CTC trends as a primary outcome measure.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30212 - Surgery
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of surgical oncology
ISSN
0022-4790
e-ISSN
1096-9098
Volume of the periodical
132
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
1052-1057
UT code for WoS article
001561398900001
EID of the result in the Scopus database
2-s2.0-105014871971