Specific microRNAs for heart failure: reference values in whole blood
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F25%3AE0111961" target="_blank" >RIV/00843989:_____/25:E0111961 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/25:A2603DA9
Result on the web
<a href="https://doi.org/10.3390/biomedicines13102559" target="_blank" >https://doi.org/10.3390/biomedicines13102559</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biomedicines13102559" target="_blank" >10.3390/biomedicines13102559</a>
Alternative languages
Result language
angličtina
Original language name
Specific microRNAs for heart failure: reference values in whole blood
Original language description
Background: The objective of this study was to validate reference values for eight selected microRNAs (miRNAs) in a population of healthy individuals. The selected miRNAs (hsa-miR-21-5p, hsa-miR-23a-3p, hsa-miR-142-5p and hsa-miR-126-3p, hsa-miR-499a-5p, hsa-miR-195-5p, hsa-miR-1-3p, hsa-miR-29a-3p) have an important role in heart failure. Methods: Ninety-nine individuals were selected for this study. Specific microRNAs were isolated from whole blood and quantified using the microRNA enzymatic immunoassay (miREIA) method. Reference intervals were evaluated with respect to age and sex. Statistical analyses were performed using MedCalc (v22.021) and R software, Version 4.1.2. Results: Reference values (2.5th and 97.5th percentile values and their 90% confidence intervals) were determined for hsa-miR-21-5p: 1.45 to 96.3 pmol/L, hsa-miR-23a-3p: 13.0 to 432 pmol/L, hsa-miR-126-3p: 5.67 to 66.5 pmol/L, hsa-miR-142-5p: 37.4 to 293 pmol/L, hsa-miR-195-5p: 11.5 to 254 pmol/L, hsa-miR-1-3p: 50.6 to 1800 pmol/L, hsa-miR-499a-5p: 8.90 to 82.5 pmol/L and hsa-miR-29a-3p: 22.9 to 210 pmol/L. The median age of the included individuals was 44 years (range: 23–75 years). No sex-related differences were observed in the reference intervals of the microRNAs (p < 0.05). Except for hsa-miR-21-5p (RS = -0.208; p = 0.043), no significant age-related associations were found for the other microRNAs (p < 0.05). However, due to the limited number of individuals in the stratified subgroups, reference intervals were not calculated for these subgroups. Conclusions: In this study, reference intervals for eight specific miRNAs associated with heart failure were determined. The results are unique for assessment in further clinical research, given that reference intervals in absolute values have not yet been published.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10609 - Biochemical research methods
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedicines
ISSN
2227-9059
e-ISSN
2227-9059
Volume of the periodical
13
Issue of the periodical within the volume
10
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
1-15
UT code for WoS article
001603802600001
EID of the result in the Scopus database
2-s2.0-105020288616