Mutations in target genes of succinate dehydrogenase inhibitors and demethylation inhibitors in Ramularia collo-cygni in Europe

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F25328859%3A_____%2F19%3AN0000010" target="_blank" >RIV/25328859:_____/19:N0000010 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15310/19:73596553

Result on the web

<a href="https://link.springer.com/article/10.1007/s41348-019-00246-4" target="_blank" >https://link.springer.com/article/10.1007/s41348-019-00246-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s41348-019-00246-4" target="_blank" >10.1007/s41348-019-00246-4</a>

Result language

angličtina

Original language name

Mutations in target genes of succinate dehydrogenase inhibitors and demethylation inhibitors in Ramularia collo-cygni in Europe

Original language description

Ramularia collo-cygni is a devastating plant pathogen of barley with an increasing importance in Europe and several other barley growing regions worldwide. R. collo-cygni is a pathogen with potential to adapt rapidly to environmental changes and is classified as a "high-risk" phytopathogen with respect to the evolution of fungicide resistance. Quinone-outside inhibitors (QoIs), demethylation inhibitors (DMIs) and succinate dehydrogenase inhibitors (SDHIs) represent three major fungicide classes that are frequently used to control a broad range of relevant cereal pathogens. However, in recent years R. collo-cygni has acquired resistance to QoIs; in addition reduced efficacy of SDHI- and DMI-containing products has been observed. In this study, we have investigated the frequency of SDHI- and DMI-adapted isolates in a European population of R. collo-cygni and evaluated the underlying resistance mechanisms towards both fungicide classes. Several mutations in the target genes of SDHIs were detected in the population of R. collo-cygni under investigation (B-H266Y/R, B-T267I, B-I268V, C-N87S, C-H146R, C-H153R and some others) with increasing frequencies since 2014. SDHI resistance in R. collo-cygni is mainly driven by both the presence of mutations and the high frequency of such mutations in the population. Additionally, DMI-adapted isolates of R. collo-cygni were found at a high frequency in the countries under investigation. Fifteen different Cyp51 haplotypes were detected in the set of isolates from 2009 to 2017. The most frequent haplotype in 2017 was C1 haplotype, which comprises three mutations in Cyp51 and shows a substantial increase in EC50 values to DMIs compared with other isolates. As R. collo-cygni has adapted to several groups of fungicides in many regions in Western Europe, future control of this highly diverse and adaptable pathogen must focus on new molecules, choosing resistant varieties and the improvement in seed hygiene standards.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

40106 - Agronomy, plant breeding and plant protection; (Agricultural biotechnology to be 4.4)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF PLANT DISEASES AND PROTECTION

ISSN

1861-3829

e-ISSN

1861-3837

Volume of the periodical

126

Issue of the periodical within the volume

5

Country of publishing house

DE - GERMANY

Number of pages

13

Pages from-to

447-459

UT code for WoS article

000491548600010

EID of the result in the Scopus database

2-s2.0-85068929551