Erythroid Transcription Factor GATA-1 Binds and Represses PU.1 Gene: Candidate Mechanism of Epigenetic Repression of PU.1 and Inefficient Erythropoiesis in MDS.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26424991%3A_____%2F13%3A%230000038" target="_blank" >RIV/26424991:_____/13:#0000038 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Erythroid Transcription Factor GATA-1 Binds and Represses PU.1 Gene: Candidate Mechanism of Epigenetic Repression of PU.1 and Inefficient Erythropoiesis in MDS.

Original language description

GATA-1 binds and represses PU.1 gene during early erythroid differentiation, however this is likely not fully completed in MDS and therefore erythroid differentiation is not efficient. Distribution of chromatin marks along side PU.1 upstream gene regiondisplays strong repressive pattern in high risk MDS patients.

Czech name

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Czech description

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Type

A - Audiovisual production

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/FR-TI2%2F509" target="_blank" >FR-TI2/509: *Development of kit for testing molecular effects of anti-tumor drugs on chromatin structure</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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