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UTILITY OF CELL-FREE TUMOR DNA IN CLINICAL MANAGEMENT OF COLORECTAL CANCER PATIENTS

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26475821%3A_____%2F12%3A%230000154" target="_blank" >RIV/26475821:_____/12:#0000154 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.ueg.eu/fileadmin/user_upload/documents/Week13/UEG_Week_2012.Final_Programme.pdf" target="_blank" >http://www.ueg.eu/fileadmin/user_upload/documents/Week13/UEG_Week_2012.Final_Programme.pdf</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    UTILITY OF CELL-FREE TUMOR DNA IN CLINICAL MANAGEMENT OF COLORECTAL CANCER PATIENTS

  • Original language description

    Poster: Patients with advanced stages of malignant tumors have elevated levels of circulating free DNA (cellfree DNA cfDNA) in peripheral blood. Under certain condition, examination of tumor cfDNA can substitute conventional tissue profiling from biopsies or resections with minimal invasivity. AIMS&METHODS: In the present work we demonstrate practical use of cfDNA examination in predictive KRAS testing as well as for monitoring of therapy response and the long term course of the disease. The initial group consisted of 204 patients in various confirmed stages of colon and rectal cancers undergoing either surgical treatment or chemotherapy. We have acquired tissue samples from primary and/or metastatic sites. In addition, plasma samples were acquired periodically over the course of the disease treatment. Mutation-based cfDNA detection was performed using a ?classic? panel of somatic mutations covering APC, KRAS, BRAF, PIK3CA and TP53 genes. RESULTS: The cfDNA detection rates were in corr

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NS9809" target="_blank" >NS9809: Use of New Molecular Genetic Methods for the Early Detection of Disease Progression in Patients with Resectable, Primary Colorectal Carcinoma Based On Circulating Tumor Cells and Free Tumor Nucleic Acids.</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů