UTILITY OF CELL-FREE TUMOR DNA IN CLINICAL MANAGEMENT OF COLORECTAL CANCER PATIENTS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26475821%3A_____%2F12%3A%230000154" target="_blank" >RIV/26475821:_____/12:#0000154 - isvavai.cz</a>
Result on the web
<a href="http://www.ueg.eu/fileadmin/user_upload/documents/Week13/UEG_Week_2012.Final_Programme.pdf" target="_blank" >http://www.ueg.eu/fileadmin/user_upload/documents/Week13/UEG_Week_2012.Final_Programme.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
UTILITY OF CELL-FREE TUMOR DNA IN CLINICAL MANAGEMENT OF COLORECTAL CANCER PATIENTS
Original language description
Poster: Patients with advanced stages of malignant tumors have elevated levels of circulating free DNA (cellfree DNA cfDNA) in peripheral blood. Under certain condition, examination of tumor cfDNA can substitute conventional tissue profiling from biopsies or resections with minimal invasivity. AIMS&METHODS: In the present work we demonstrate practical use of cfDNA examination in predictive KRAS testing as well as for monitoring of therapy response and the long term course of the disease. The initial group consisted of 204 patients in various confirmed stages of colon and rectal cancers undergoing either surgical treatment or chemotherapy. We have acquired tissue samples from primary and/or metastatic sites. In addition, plasma samples were acquired periodically over the course of the disease treatment. Mutation-based cfDNA detection was performed using a ?classic? panel of somatic mutations covering APC, KRAS, BRAF, PIK3CA and TP53 genes. RESULTS: The cfDNA detection rates were in corr
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS9809" target="_blank" >NS9809: Use of New Molecular Genetic Methods for the Early Detection of Disease Progression in Patients with Resectable, Primary Colorectal Carcinoma Based On Circulating Tumor Cells and Free Tumor Nucleic Acids.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů