CLINICAL UTILITY OF MOLECULAR CHARACTERIZATION OF GASTRIC CANCERS BASED ON SOMATIC MUTATIONS AND GENE AMPLIFICATIONS

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26475821%3A_____%2F13%3A%230000191" target="_blank" >RIV/26475821:_____/13:#0000191 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
CLINICAL UTILITY OF MOLECULAR CHARACTERIZATION OF GASTRIC CANCERS BASED ON SOMATIC MUTATIONS AND GENE AMPLIFICATIONS
Original language description
Poster presenting clinical utility of molecular characterization of gastric cancer. According to the Czech national cancer register the prognosis of gastric cancer patients has remained unchanged over the course of the past 20 years. With a 5-year survival of just 30% (for all stages) it is the third most fatal malignancy of the gastrointestinal tract and sixth overall among solid cancers. The recent trends in discovery and use of biomarkers in other cancers have been mainly derived from detailed tumorprofiling. Somatic mutations and gene amplifications are among the molecular aberations frequently studied. The conclusion is: Somatic mutations are not associated with localization or stage and are likely not factors in prognosis of the disease. Molecular classification of gastric cancer based on gene amplification patterns results in distinct tumor similarities that may have clinical relevance for clinical management of gastric cancer.
Czech name
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Czech description
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Project
<a href="/en/project/NT13640" target="_blank" >NT13640: Applicability of a panel of molecular markers in clinical management of advanced gastric cancer</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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