ABERRANT AMPLIFICATION OF RECEPTOR TYROSIN-KINASES (RTK) INVOLVED IN CELL CYCLE SIGNALING APPEARS TO DETERMINE PROGNOSIS OF GASTRIC CANCER PATIENTS

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26475821%3A_____%2F14%3A%230000205" target="_blank" >RIV/26475821:_____/14:#0000205 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
ABERRANT AMPLIFICATION OF RECEPTOR TYROSIN-KINASES (RTK) INVOLVED IN CELL CYCLE SIGNALING APPEARS TO DETERMINE PROGNOSIS OF GASTRIC CANCER PATIENTS
Original language description
Poster describeng aberant amplification of receptor tyrosin-kinases. Follow-up colonoscopies were performed on 30 patients. Recurrence adenoma within 3 years was diagnosed in 11 (37%) of cases. 19 patients (63%) had no adenoma presence or the interval ofrecurrence adenoma was longer than 3 years. Somatic mutations were found in 10 patient in the first and 8 patients in the second group, respectively (90% and 42%; p=0.0249). Mutations were observed in 60% (29/48) of patients with advanced adenoma and in28% (8/28) with early adenoma. Conclusion: Follow-up with recommended intervals is the important tool for prevention of colorectal cancer development, especially in an important subgroup of patients susceptible to recurrent adenoma development. The pilot results imply that the chromosomal instability phenotype (CIN), uncovered by genetic testing of the autonomous tissue, may represent the independent factor of such recurrences increased risk.
Czech name
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Czech description
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Project
<a href="/en/project/NT13640" target="_blank" >NT13640: Applicability of a panel of molecular markers in clinical management of advanced gastric cancer</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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