Evaluation of circulating-tumor DNA as a source for molecular phenotyping of colorectal tumors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26475821%3A_____%2F15%3A%230000211" target="_blank" >RIV/26475821:_____/15:#0000211 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Evaluation of circulating-tumor DNA as a source for molecular phenotyping of colorectal tumors
Original language description
Poster describing Evaluation of circulating-tumor DNA as a source for molecular phenotyping of colorectal tumors. Patients with advanced stages of malignant tumors often have elevated levels of circulating free DNA (cell-free DNA, cfDNA) in peripheral blood. cfDNA is released as a result of apoptosis and necrosis processes, both directly from the mass of the tumor and from surrounding non-tumor tissue. In terms of diagnostic and therapeutic procedure, especially tumor cfDNA component is important from overall cfDNA amount. Its presence can facilitate acquisition of DNA material for tumor molecular profiling to diagnosis and prediction of patients response to biological targeted therapies.All this without the implementation of frequent invasive and costly investigations. In this work we present utility of ctDNA for the determination of tumor phenotype within the basic division into the mutator phenotype (microsatellite instability, MSI and chromosomal instability, CIN) or methylator phe
Czech name
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Czech description
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Project
<a href="/en/project/NT14383" target="_blank" >NT14383: Use of cfDNA as a new intention for minimally-invasive diagnosis and precise molecular classification of colorectal tumors.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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