IDH1/2 Mutation and MGMT Promoter Methylation - The Relevant Survival Predictors in Czech Patients With Brain Gliomas

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26475821%3A_____%2F16%3AN0000008" target="_blank" >RIV/26475821:_____/16:N0000008 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10332504 RIV/61383082:_____/16:00000251

Result on the web

<a href="http://fb.cuni.cz/file/5820/fb2016a0024.pdf" target="_blank" >http://fb.cuni.cz/file/5820/fb2016a0024.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

IDH1/2 Mutation and MGMT Promoter Methylation - The Relevant Survival Predictors in Czech Patients With Brain Gliomas

Original language description

Gliomas are a heterogeneous group of tumours varying in prognosis, treatment approach, and overall survival. Recently, novel markers have been identified which are linked to patient prognosis and therapeutic response. Especially the mutation of the enzyme isocitrate dehydrogenase 1 or 2 (IDH1/2) gene and the O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status seem to be the most important predictors of survival. From 2012 to 2015, 94 Czech patients with primary brain tumours were enrolled into the study. The IDH1/2 mutation was detected by denaturing capillary electrophores.The methylation status of the MGMT gene and other 46 genes was revealed by MS-MLPA. In all 94 patients, the clinical data were correlated with molecular markers by Kaplan-Meier analyses and Cox regression model.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/NT14253" target="_blank" >NT14253: Epigenetic markers influencing the behavior of brain tumors</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica (Praha)

ISSN

0015-5500

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

5

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

194-202

UT code for WoS article

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EID of the result in the Scopus database

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