A Dosimetric and Biological Model for Neutron Capture Therapy (NCT) Experiments
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26722445%3A_____%2F25%3AN0000013" target="_blank" >RIV/26722445:_____/25:N0000013 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0969804325005780" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0969804325005780</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.apradiso.2025.112233" target="_blank" >10.1016/j.apradiso.2025.112233</a>
Alternative languages
Result language
angličtina
Original language name
A Dosimetric and Biological Model for Neutron Capture Therapy (NCT) Experiments
Original language description
A hybrid Monte Carlo approach using MCNP in combination with the cell-level code Monte Carlo Damage Simulation (MCDS) is presented to support the design and analysis of experiments for the evaluation of gadolinium (Gd) based agents in neutron capture therapy (NCT). Monoenergetic neutrons (0.025 eV–15 MeV) and polyenergetic neutron beams from NEUTRA, ICON (PSI, Switzerland), and HK1 (LVR-15, Czech Republic) were used to estimate the relative biological effectiveness (RBE) of NCT for the biologically critical endpoint of DNA double strand break (DSB) production relative to 60Co γ-rays. Moreover, microdosimetric spectra of protons, electrons, alpha particles and heavy recoils were determined for the aforementioned neutron beams, to enhance the interpretation of energy deposition in subcellular structrures. The proposed, hybrid model and methodology builds on well-validated dosimetry and biophysical models at different spatial scales to create a versatile and generalized framework to estimate dosimetric parameters and RBE. This approach facilitates comparisons between NCT and low linear energy transfer (LET) radiation alternatives.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10303 - Particles and field physics
Result continuities
Project
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Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Applied Radiation and Isotopes
ISSN
0969-8043
e-ISSN
1872-9800
Volume of the periodical
226
Issue of the periodical within the volume
December
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
1-7
UT code for WoS article
001597077200001
EID of the result in the Scopus database
2-s2.0-105018318882