Comprehensive assessment of electrospun scaffolds hemocompatibility

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F17%3A00005345" target="_blank" >RIV/27283933:_____/17:00005345 - isvavai.cz</a>
Alternative codes found
RIV/46747885:24410/18:00004140 RIV/67985891:_____/18:00482099 RIV/68407700:21220/18:00315051
Result on the web
<a href="https://api.elsevier.com/content/article/eid/1-s2.0-S0928493116307913" target="_blank" >https://api.elsevier.com/content/article/eid/1-s2.0-S0928493116307913</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.msec.2017.05.011" target="_blank" >10.1016/j.msec.2017.05.011</a>

Result language
angličtina
Original language name
Comprehensive assessment of electrospun scaffolds hemocompatibility
Original language description
Biodegradable polyesters, namely polycaprolactone (PCL) and copolymer of polylactide and polycaprolactone (PLCL) were electrospun into various fibrous structures and their hemocompatibility was evaluated in vitro. Firstly, hemolytic effect was evaluated upon incubation with diluted whole blood. The results showed that the degree of hemolysis depended on chemical composition and fibrous morphology. Electrospun polycaprolactone induced slight degree of hemolysis depending on its molecular weight and fibrous morphology; copolymer PLCL did not cause detectable hemolysis. The influence of coagulation pathways was examined by measurement of coagulation times. It was showed that intrinsic coagulation pathway assessed by activated partial thromboplastin time (APTT) was moderately accelerated after incubation with PCL and prolonged after incubation with copolymer PLCL. Extrinsic activation of coagulation tested by prothrombin time (PT) was slightly accelerated after incubation with all tested electrospun samples. Thrombogenicity assessment of fibrous samples revealed high thrombogenic properties of fibrous materials that was comparable to high degree of collagen thrombogenicity. The level of platelet activation was dependent on chemical composition and surface morphology of tested materials.
Czech name
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Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30230 - Other clinical medicine subjects

Project
<a href="/en/project/NV15-29241A" target="_blank" >NV15-29241A: Nanofibrous Biodegradable Small-Diameter Vascular Bypass Graft</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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