Poster Abstracts
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F17%3A00005389" target="_blank" >RIV/27283933:_____/17:00005389 - isvavai.cz</a>
Result on the web
<a href="https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111/tme.12417" target="_blank" >https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111/tme.12417</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/tme.12417" target="_blank" >10.1111/tme.12417</a>
Alternative languages
Result language
angličtina
Original language name
Poster Abstracts
Original language description
Therapeutic plasma exchange (TPE) is a therapeuticoption in a variety of diseases. In most indications, albumin is recommended as a replacement fluid. During TPE coagulation factors areremoved and a depletion of coagulation factors results. We have found norecommendations for the assessment of haemostasis and managementof bleeding risk in patients undergoing TPE. The increased bleeding riskis important in the management of these patients. The only published data about assessment of haemostasis by rotational thromboelastome-try (ROTEM) in patients after TPE are in patients using TPE beforecadaveric donor kidney transplant.1WefoundnodataofROTEMusein patients, where TPE protocols with series of TPE were used. We have performed rotational thromboelastometry in patients with Guillain-Barré syndrome undergoing TPE therapy. All patients had a series of TPE, the interval between TPE was 24–48 hours.Albumin was used as a replacement fluid. We performed standard coagulation tests and rotational thromboelastometry before and after each TPE. TPE reduced fibrinogen levels both in a standard laboratorytest and according to FIBTEM (MCF). Clotting time (CT) and clot formation time (CFT) were prolonged both in INTEM and EXTEM. Standard coagulation tests were also prolonged (aPTT, INR). Thromboelastometry results reflected a serious coagulopathy. The coagulopathybetween each TPE in most cases corrected spontaneously, but in somecases the coagulopathy and especially the reduced fibrinogen level prevailed even after 48 hours and haemostasis did not normalise betweeneach TPE session. Haemostasis is severely influenced by TPE with albumin. The resulting coagulopathy should be assessed individually in eachpatient. The bleeding risk should be monitored and measured beforeeach invasive procedure and the timing of invasive procedures (centralvein cannulation, tracheostomy or spinal tap) should be individualisedaccording to results. It should be taken into consideration that in somepatients the coagulopathy prevails throughout the series of TPE and corrects spontaneously only after the TPE series is over. Rotational thromboelastometry can be used to assess haemostasis and bleeding risk inthese patients.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
30230 - Other clinical medicine subjects
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Transfusion Medicine
ISBN
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ISSN
0958-7578
e-ISSN
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Number of pages
2
Pages from-to
22-71
Publisher name
Wiley
Place of publication
Oxford
Event location
Florencie
Event date
Jan 1, 2017
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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