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Poster Abstracts

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F17%3A00005389" target="_blank" >RIV/27283933:_____/17:00005389 - isvavai.cz</a>

  • Result on the web

    <a href="https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111/tme.12417" target="_blank" >https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111/tme.12417</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/tme.12417" target="_blank" >10.1111/tme.12417</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Poster Abstracts

  • Original language description

    Therapeutic plasma exchange (TPE) is a therapeuticoption in a variety of diseases. In most indications, albumin is recommended as a replacement fluid. During TPE coagulation factors areremoved and a depletion of coagulation factors results. We have found norecommendations for the assessment of haemostasis and managementof bleeding risk in patients undergoing TPE. The increased bleeding riskis important in the management of these patients. The only published data about assessment of haemostasis by rotational thromboelastome-try (ROTEM) in patients after TPE are in patients using TPE beforecadaveric donor kidney transplant.1WefoundnodataofROTEMusein patients, where TPE protocols with series of TPE were used. We have performed rotational thromboelastometry in patients with Guillain-Barré syndrome undergoing TPE therapy. All patients had a series of TPE, the interval between TPE was 24–48 hours.Albumin was used as a replacement fluid. We performed standard coagulation tests and rotational thromboelastometry before and after each TPE. TPE reduced fibrinogen levels both in a standard laboratorytest and according to FIBTEM (MCF). Clotting time (CT) and clot formation time (CFT) were prolonged both in INTEM and EXTEM. Standard coagulation tests were also prolonged (aPTT, INR). Thromboelastometry results reflected a serious coagulopathy. The coagulopathybetween each TPE in most cases corrected spontaneously, but in somecases the coagulopathy and especially the reduced fibrinogen level prevailed even after 48 hours and haemostasis did not normalise betweeneach TPE session. Haemostasis is severely influenced by TPE with albumin. The resulting coagulopathy should be assessed individually in eachpatient. The bleeding risk should be monitored and measured beforeeach invasive procedure and the timing of invasive procedures (centralvein cannulation, tracheostomy or spinal tap) should be individualisedaccording to results. It should be taken into consideration that in somepatients the coagulopathy prevails throughout the series of TPE and corrects spontaneously only after the TPE series is over. Rotational thromboelastometry can be used to assess haemostasis and bleeding risk inthese patients.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

  • OECD FORD branch

    30230 - Other clinical medicine subjects

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Transfusion Medicine

  • ISBN

  • ISSN

    0958-7578

  • e-ISSN

  • Number of pages

    2

  • Pages from-to

    22-71

  • Publisher name

    Wiley

  • Place of publication

    Oxford

  • Event location

    Florencie

  • Event date

    Jan 1, 2017

  • Type of event by nationality

    EUR - Evropská akce

  • UT code for WoS article