Safety And Efficacy of Routine Endovascular Thrombectomy in Acute Occlusive Stroke Recorded in the International Sits Thrombectomy Register - an Observational study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F18%3A00005510" target="_blank" >RIV/27283933:_____/18:00005510 - isvavai.cz</a>

Result on the web

<a href="http://journals.sagepub.com/doi/pdf/10.1177/2396987318770127" target="_blank" >http://journals.sagepub.com/doi/pdf/10.1177/2396987318770127</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/2396987318770127" target="_blank" >10.1177/2396987318770127</a>

Result language

angličtina

Original language name

Safety And Efficacy of Routine Endovascular Thrombectomy in Acute Occlusive Stroke Recorded in the International Sits Thrombectomy Register - an Observational study

Original language description

Background and Aims: Endovascular thrombectomy (EVT) significantly improved functional outcomes among patients with anterior circulation acute ischemic stroke (ACIS) due to evaluate the safety and efficacy of EVT in ACIS recorded in the SITS International Thrombectomy Register (TBYR) and compared to patients in the EVT arms of pooled randomized controlled trials (RCTs). Method: We identified centres recording>=10 consecutive patients in the SITS-TBYR with at least 70% of available modified Rankin Scyle (mRS) at 3-months during 2014 to 2017. We analysed LAO as intracranial ICA, MI, M2, AI, A2 treated with thrombectomy with of without prior IVT given within 4,5 hours of stroke onset. Primary efficacy outcome was functional independence (mRS score 0-2) at 3 months and safety outcomes were symptomatic intracranial haemorrhage (SICH) per modified SITS-MOST (any haemorrhagic transformation on 22-36 h imaging scans and worsening of > = 4p on NIHSS within 24 h and death within 3 months. Results: In total. 2780 (89% with available 3 month outcomes) patients from 24 centres were treated with thrombectomy: 1751 (63%) with prior IVT, 1029 (37%) without. Median age was 72 (61-80), vs. 68 (57-77) years; baseline NIHSS score was 17 (12-21) vs. 17 (14-20) in SITS-EVT vs. RCTs. Functional independence at 3 months was 45,9% (95% CI: 43.9-47,9), vs. 46,0% 42,0-50,0) and death 18,2% (16,7-19,7) vs. 15,3% (12,7-18,4), SICH 4,8%(4,1-5,7) vs. 4,4% (3,0-6,4) in SITS-EVT vs. RCTs. Conclusion: Our results demonstrated that thrombectomy is safe and effective in routine clinical use in ACIS with LAO.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů