Background: HELLP syndome is a life-threatening condition complicating 0,5-0,9% of all pregnancies. It is characterized by endothelial dysfunction associated with microangiopathy. The syndrome is named after the triad of diagnostic criteria: Hemolysis, Elevated Liver enzyme levels, and Low Platelet levels, and it is mostly classified using The Mississippi-Triple Class System. The basic treatment usually involves early delivery, antihypertensive drugs, high-dose magnesium sulphate, corticosteroids and close monitoring of fluid balance and coagulation parameters. About 30% of the cases develop
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F18%3A00006514" target="_blank" >RIV/27283933:_____/18:00006514 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Background: HELLP syndome is a life-threatening condition complicating 0,5-0,9% of all pregnancies. It is characterized by endothelial dysfunction associated with microangiopathy. The syndrome is named after the triad of diagnostic criteria: Hemolysis, Elevated Liver enzyme levels, and Low Platelet levels, and it is mostly classified using The Mississippi-Triple Class System. The basic treatment usually involves early delivery, antihypertensive drugs, high-dose magnesium sulphate, corticosteroids and close monitoring of fluid balance and coagulation parameters. About 30% of the cases develop
Original language description
Background: HELLP syndome is a life-threatening condition complicating 0,5-0,9% of all pregnancies. It is characterized by endothelial dysfunction associated with microangiopathy. The syndrome is named after the triad of diagnostic criteria: Hemolysis, Elevated Liver enzyme levels, and Low Platelet levels, and it is mostly classified using The Mississippi-Triple Class System. The basic treatment usually involves early delivery, antihypertensive drugs, high-dose magnesium sulphate, corticosteroids and close monitoring of fluid balance and coagulation parameters. About 30% of the cases develop after the delivery with a part of patients non-reacting to usual therapy. These patients may suffer from PTMS – postpartum thrombotic microangiopathic syndrome. Its symptoms remind of HELLP syndrome by its laboratory parameters and clinical signs, these however do not respond to classic therapy and even progressively deteriorate. The Hemolytic-uraemic syndrome (HUS), Thrombotic thrombocytopenic purpura (TTP), Systemic lupus erythematosus (SLE) and Antiphospholipide syndrome (APS) are some of the diseases included. On the basis of microangiopathy the disseminated intravascular coagulation and multiorgan failure may develop and repeated Postpartum plasma exchange (PPEX) is often necessary.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů