Interactions between Anti-VEGF Therapy and Antitumor Immunity as a Ptentional Therapeutic Strategy in Colorectal Cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F19%3A00006948" target="_blank" >RIV/27283933:_____/19:00006948 - isvavai.cz</a>
Result on the web
<a href="https://actamedica.lfhk.cuni.cz/62/3/0127/" target="_blank" >https://actamedica.lfhk.cuni.cz/62/3/0127/</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Interactions between Anti-VEGF Therapy and Antitumor Immunity as a Ptentional Therapeutic Strategy in Colorectal Cancer
Original language description
There is a growing corpus of evidence indicating that anti-VEGF therapy may normalize the abnormal tumor vasculature with potential to re-program the tumor immune microenvironment to a more immunosupportive profile. Tumor vessel normalization increases tumor perfusion, and, consequently, oxygen and nutrient supply, and thus can be assumed to improve the general response to anticancer immunotherapy. The increased antitumor immunity responses seen following anti-VEGF therapy may also be associated with the inhibition of the immunosuppressive action deployed by CEGF on effector T cells. Bearing in mind th recent advanced of combination immunotherapy, combination of anti-VEGF therapy with immune checkpoint inhibitors now appear to represent an attractive strategy. Key to the successful implementaion of a combination strategy for treating cancer is understading the interaction of these two therapeutic interventions, particularly in regards to appropiate reprogramming of the tumor immune microenviromet to improve antitumor immunity
Czech name
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Czech description
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Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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