Obstructive sleep apnea, depression and cognitive impairment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F20%3A00008305" target="_blank" >RIV/27283933:_____/20:00008305 - isvavai.cz</a>

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S1389945720301295/" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1389945720301295/</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Obstructive sleep apnea, depression and cognitive impairment

Original language description

Objective Obstructive sleep apnea (OSA) is a severe di-sorder with a high prevalence. Psychiatric comorbidities, especially depressive symptoms and cognitive dysfunction, are often described in OSA patients. This narra-tive review aims to examine: (1) the relati-onship between obstructive sleep apnea syndrome (OSAS) and depressive and co-gnitive symptoms, and (2) the effect of OSAS treatment on psychiatric symptoms. Method Articles that were published between January 1990 and August 2018 were searched and ex-tracted via PubMed, and Web of Science data-bases. Authors analyzed the papers and its references using the following keywords: ob-structive sleep apnea, depression, cognitive dysfunction, anxiety disorders, and continuous positive airway pressure (CPAP). A total of 632 articles were nominated. After the selection according to the inclusion and exclusion crite-ria, 172 articles were chosen. After complete inspection of the full texts, finally, 58 papers were selected. Secondary papers from the reference lists of the primarily designated pa-pers were also searched, assessed for suitabili-ty, and added to the first list of the papers (n = 67). In total, 125 papers were included in this review. Results There is a significant overlap in depressive, anxious and OSA symptoms. Studies also show that attention, working memory, episodic me-mory, and executive functions are decreased in OSA. Conversely, most of verbal functions remain intact and variable results are found in psychomotor speed. Several studies implicated that in some fields of cognitive functions (eg, attention) deficit caused by untreated OSA can be irreversible and shows only partial recovery after a period of treatment with CPAP. Conclusions Untreated OSA impacts affective disorders, and often leads to decline of cognitive functi-ons or even leads to permanent brain damage. Further studies are needed to analyze the connection between OSA and affective disor-ders, anxiety disorders and its effect on cogni-tive functions more thoroughly, especially in the context of CPAP treatment.

Czech name

—

Czech description

—

Type

O - Miscellaneous

CEP classification

—

OECD FORD branch

30215 - Psychiatry

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů