Impact of immunotherapy on Real-world survival outcomes in metastatic renal cell carcinoma.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F23%3AN0000003" target="_blank" >RIV/27283933:_____/23:N0000003 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/23:10471047 RIV/00216208:11110/23:10471047 RIV/00216208:11140/23:10471047 RIV/61989592:15110/23:73621206 and 8 more
Result on the web
<a href="https://link.springer.com/article/10.1007/s11523-023-01013-0" target="_blank" >https://link.springer.com/article/10.1007/s11523-023-01013-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11523-023-01013-0" target="_blank" >10.1007/s11523-023-01013-0</a>
Alternative languages
Result language
angličtina
Original language name
Impact of immunotherapy on Real-world survival outcomes in metastatic renal cell carcinoma.
Original language description
"Background: Treatment options for metastatic renal cell carcinoma (mRCC) are rapidly expanding, and immunotherapy using checkpoint inhibitors is a first- or second-line option for most patients. Objective: The objective of the present retrospective analysis was to explore the real-world impact of checkpoint inhibitor-based immunotherapy compared with therapy using other types of targeted therapies using a large real-world database. Methods: RenIS, a registry of patients with mRCC was used as a data source. Outcomes were compared for cohorts treated with TKIs or mTOR inhibitors only [targeted therapy (TT) cohort] versus patients who received immunotherapy (IO) using a checkpoint inhibitor in any line of treatment (IO cohort). Data from a total of 1981 patients were extracted from the registry, including 1767 patients in the TT cohort and 214 patients in the IO cohort. Results: The median overall survival from the initiation of first-line treatment was 24.5 months versus not reached (p < 0.001) in the TT cohort versus the IO cohort, respectively [HR 0.23, 95% CI (0.17-0.31), p < 0.001]. The probability of 5-year survival was 24.2 versus 67.9% in the TT cohort versus the IO cohort, respectively. Immunotherapy in any line of treatment was associated with a lower risk of death. Overall survival was superior for patients receiving immunotherapy as the first or second treatment line compared with patients treated with non-immunological targeted therapy. Conclusion: In real-world patients with mRCC, immunotherapy is associated with significant survival benefit. The present retrospective analysis shows the real-world benefit of second-line immunotherapy in patients previously treated with tyrosine-kinase inhibitors."
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/NU21-03-00539" target="_blank" >NU21-03-00539: The effect of endoplasmic reticulum stress on the immune status of tumors and the efficiency of immunotherapy in the treatment of ovarian and renal cell carcinoma</a><br>
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Targeted Oncology
ISSN
1776-2596
e-ISSN
1776-260X
Volume of the periodical
18
Issue of the periodical within the volume
6
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
893-903
UT code for WoS article
001104868200001
EID of the result in the Scopus database
2-s2.0-85176434025