Pancreatic Neuroendocrine Microtumors (WHO 2022) Are Not Always Low Grade Neoplasms: A Case with a Highly Increased Proliferation Rate
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F24%3AN0000014" target="_blank" >RIV/27283933:_____/24:N0000014 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/24:00084917
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/38403790/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/38403790/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12022-024-09802-7" target="_blank" >10.1007/s12022-024-09802-7</a>
Alternative languages
Result language
angličtina
Original language name
Pancreatic Neuroendocrine Microtumors (WHO 2022) Are Not Always Low Grade Neoplasms: A Case with a Highly Increased Proliferation Rate
Original language description
Traditionally considered non-functional low proliferative benign neuroendocrine proliferations measuring less than 5 mm, pancreatic (neuro)endocrine microadenomas are now classifed as pancreatic neuroendocrine microtumors in the 2022 WHO classifcation of endocrine and neuroendocrine tumors. This case report discussed the features of an incidentally identifed 4.7-mm glucagon-expressing pancreatic neuroendocrine microtumor with MEN1 mutation only, chromosomally stable and an epigenetic alpha-like phenotype. The tumor was associated with an unexplained increased proliferation rate in Ki-67 of 15%. There was no associated DAXX/ATRX defciency. The presented case challenges the conventional thought of a low proliferative disease of the so-called “pancreatic neuroendocrine microadenomas” and provides additional support to the 2022 WHO classifcation that also requires grading of these neoplasms. Despite exhibiting molecular features of less aggressive behavior, the case also underscores the biological complexity of pancreatic neuroendocrine microtumors. By recognizing the heterogenous spectrum of neuroendocrine neoplasms, the current case also contributes to ongoing discussions on how to optimize the clinical management of such tumors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Endocrine Pathology
ISSN
1046-3976
e-ISSN
1559-0097
Volume of the periodical
35
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
147-153
UT code for WoS article
001170279400001
EID of the result in the Scopus database
2-s2.0-85185972541