Prevalence and clinical significance of liver function abnormalities in patients with acute heart failure

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F15%3AN0000001" target="_blank" >RIV/27661989:_____/15:N0000001 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/15:00061056 RIV/00216224:14110/15:00082185 RIV/00216208:11110/15:10313284 RIV/00216208:11120/15:43909182 and 3 more

Result on the web

<a href="https://biomed.papers.upol.cz/artkey/bio-201503-0016_Prevalence_and_clinical_significance_of_liver_function_abnormalities_in_patients_with_acute_heart_failure.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-201503-0016_Prevalence_and_clinical_significance_of_liver_function_abnormalities_in_patients_with_acute_heart_failure.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2014.014" target="_blank" >10.5507/bp.2014.014</a>

Result language

angličtina

Original language name

Prevalence and clinical significance of liver function abnormalities in patients with acute heart failure

Original language description

Aims. Liver pathology caused by cardiac dysfunction is relatively well recognized, however, its clinical importance has not been fully evaluated. The aim of this study was to assess the prevalence of liver function tests (LFTs) abnormalities and to identify associated factors mediating hepatic impairment in patients with acute heart failure (AHF). Methods. The AHEAD (Acute Heart Failure Database) registry is a database conducted in 9 university hospitals and 5 regional health care facilities in the Czech Republic. From December 2004 to October 2012, the data of 8818 patients were included. The inclusion criteria for the database followed the European guidelines for AHF. Serum activities of all LFTs and total bilirubin were available in 1473 patients at the baseline. Results. In patients with AHF, abnormal LFTs were seen in 76% patients (total bilirubin in 34%, gamma-glutamyltransferase in 44%, alkaline phosphatase in 20%, aspartate aminotransferase in 42%, alanine aminotransferase in 35%). Patients with cardiogenic shock were more likely to have LFTs abnormalities compared to mild AHF and pulmonary oedema. LFTs abnormalities were strongly associated with AHF severity (left ventricular ejection fraction and NYHA functional class) and clinical manifestation. While hepatocellular LFTs pattern predominated in left sided forward AHF, cholestatic profile occurred mainly in bilateral and right sided AHF. Additionally, patients with moderate to severe tricuspid regurgitation had significantly higher prevalence of abnormalities in cholestatic LFTs. Conclusions. Defining the LFTs profile typical for AHF plays an important role in management of AHF patients, since it may avoid redundant hepatic investigations and diagnostic misinterpretations.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/NS9880" target="_blank" >NS9880: Mnagment of care of patients with acute heart failure, their min-term prognosis and multivariate prognostic model.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

1804-7521

Volume of the periodical

159

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

429-436

UT code for WoS article

000364948100016

EID of the result in the Scopus database

2-s2.0-84942898201