Incorporating thyroid markers in Down syndrome screening protocols
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F17%3AN0000006" target="_blank" >RIV/27661989:_____/17:N0000006 - isvavai.cz</a>
Result on the web
<a href="https://obgyn.onlinelibrary.wiley.com/doi/10.1002/pd.5047" target="_blank" >https://obgyn.onlinelibrary.wiley.com/doi/10.1002/pd.5047</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/pd.5047" target="_blank" >10.1002/pd.5047</a>
Alternative languages
Result language
angličtina
Original language name
Incorporating thyroid markers in Down syndrome screening protocols
Original language description
ObjectiveThe article aimed to assess the benefit of incorporating maternal serum thyroid disease marker levels (thyroid-stimulating hormone and free thyroxine) into first trimester Down syndrome screening protocols. MethodsStatistical modelling was used to predict performance with and without the thyroid markers. Two protocols were considered: the combined test and the contingent cell-free DNA (cfDNA) test, where 15-40% women are selected for cfDNA because of increased risk based on combined test results. Published parameters were used for the combined test, cfDNA and the Down syndrome means for thyroid-stimulating hormone and free thyroxine; other parameters were derived from a series of 5230 women screened for both thyroid disease and Down syndrome. ResultsCombined test: For a fixed 85% detection rate, the predicted false positive rate was reduced from 5.3% to 3.6% with the addition of the thyroid markers. Contingent cfDNA test: For a fixed 95% detection rate, the proportion of women selected for cfDNA was reduced from 25.6% to 20.2%. ConclusionsWhen screening simultaneously for maternal thyroid disease and Down syndrome, thyroid marker levels should be used in the calculation of Down syndrome risk. The benefit is modest but can be achieved with no additional cost. (c) 2017 John Wiley & Sons, Ltd.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30200 - Clinical medicine
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Prenatal Diagnosis
ISSN
0197-3851
e-ISSN
1097-0223
Volume of the periodical
37
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
510-514
UT code for WoS article
000401561200013
EID of the result in the Scopus database
2-s2.0-85018935336