Anatomy and pathophysiology of nAMD

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F25%3A10003214" target="_blank" >RIV/27661989:_____/25:10003214 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Anatomy and pathophysiology of nAMD
Original language description
The lecture presented at the Vision+ expert-led webinar on Neovascular Age-Related Macular Degeneration focused on the detailed anatomy of the macula's central retina and the pathophysiological mechanisms leading to the development of neovascular (wet) age-related macular degeneration (nAMD). It discussed the roles of the retinal pigment epithelium, Bruch's membrane, and the choriocapillaris in maintaining macular integrity and how age-related changes in these structures facilitate neovascularization. Neovascular AMD is characterized by the abnormal growth of new blood vessels from the choroid into the subretinal space, whose leakiness leads to exudation, edema, hemorrhage, and subsequent photoreceptor damage with rapid central vision loss. The pathophysiology involves complex interactions among oxidative stress, inflammatory processes, genetic predispositions, and pathological angiogenesis driven primarily by vascular endothelial growth factor (VEGF). Understanding these mechanisms is critical for diagnosis, prognosis, and development of targeted therapeutic strategies.
Czech name
—
Czech description
—

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)