Low fibrinogen after intravenous thrombolysis: a possible predictor of hemorrhagic intracranial complications?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F25%3A10003515" target="_blank" >RIV/27661989:_____/25:10003515 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/ene.70191" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1111/ene.70191</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ene.70191" target="_blank" >10.1111/ene.70191</a>
Alternative languages
Result language
angličtina
Original language name
Low fibrinogen after intravenous thrombolysis: a possible predictor of hemorrhagic intracranial complications?
Original language description
Background and aims: Current Czech guidelines for treatment with intravenous thrombolysis (IVT) include the examination of coagulation parameters, including fibrinogen levels, before IVT, 6 hours and 24 hours after IVT, but there is no official recommendation on when to substitute fibrinogen, and whether to do so at all. Substitution is available in hospitals (Hemocomplettan i.v.). Fibrinogen substitution may be a way to prevent the development of bleeding complications during IVT treatment. The aim of this study was to evaluate whether a decrease in fibrinogen levels below the reference range of 1.8 g/l is associated with a higher likelihood of intracranial hemorrhage in patients with ischemic stroke treated with IVT.Methods: This multicenter retrospective study was conducted in 7 Czech centers. The study population consists of 280 patients enrolled in the observational group (divided into subgroups according to the type of hemorrhagic complication after IVT) and the control group (without hemorrhagic complication) according to the model 1:1 principle (same NIHSS, age, sex).Results: In all treatment groups (all observational subgroups as well as the control group), a decrease in fibrinogen levels was noted after IVT administration, with varying degrees of signification. A statistically significant difference (p = 0.0394) was found at 6 h after IVT administration in patients with the most clinically serious form of bleeding (parenchymal hematoma type 2), fibrinogen value 1.84 g/l versus 2.53 g/l.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Neurology
ISSN
1351-5101
e-ISSN
1468-1331
Volume of the periodical
32
Issue of the periodical within the volume
Supplement 1
Country of publishing house
US - UNITED STATES
Number of pages
1
Pages from-to
80
UT code for WoS article
001628319700875
EID of the result in the Scopus database
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