Transitions in SPMS Diagnosis and DMT Use Following Siponimod Reimbursement: Evidence from the Czech ReMuS Registry (2016-2023)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F25%3A10003520" target="_blank" >RIV/27661989:_____/25:10003520 - isvavai.cz</a>

Result on the web

<a href="https://journals.sagepub.com/doi/epub/10.1177/13524585251370533" target="_blank" >https://journals.sagepub.com/doi/epub/10.1177/13524585251370533</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/13524585251370533" target="_blank" >10.1177/13524585251370533</a>

Result language

angličtina

Original language name

Transitions in SPMS Diagnosis and DMT Use Following Siponimod Reimbursement: Evidence from the Czech ReMuS Registry (2016-2023)

Original language description

This study examines national trends in the diagnosis of secondary progressive multiple sclerosis (SPMS) in the Czech Republic between 2016 and 2023 using data from the ReMuS registry. Patients were classified either by clinical diagnosis (Cohort C; n = 722) or via the algorithm by Lorscheider et al. (Cohort D; n = 1,441). Trends were compared before and after siponimod reimbursement in 2021, assessing age, EDSS, relapse history, and exposure to disease‑modifying therapies (DMTs). Clinical SPMS diagnoses increased after 2021, whereas algorithm‑based identification remained stable. Patients were older at diagnosis and had greater prior DMT exposure, particularly high‑efficacy therapies; meanwhile, the proportion of untreated patients decreased substantially. Persistent discrepancies between clinical and algorithmic classifications highlight ongoing variability in diagnostic practice and the need for more standardised criteria for SPMS identification.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Multiple Sclerosis Journal

ISSN

1352-4585

e-ISSN

1477-0970

Volume of the periodical

31

Issue of the periodical within the volume

3 Supplement

Country of publishing house

GB - UNITED KINGDOM

Number of pages

2

Pages from-to

1430-1431

UT code for WoS article

001603659904326

EID of the result in the Scopus database

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