The fluidity changesofneutral and negativelycharged lipid model membranescaused by maltosemodified PPI G5 dendrimers

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F13%3A43885742" target="_blank" >RIV/44555601:13440/13:43885742 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The fluidity changesofneutral and negativelycharged lipid model membranescaused by maltosemodified PPI G5 dendrimers
Original language description
Dendrimers are symmetrically hyperbranched nano-sized polymers presenting vast potential in drug delivery applications. Drugs conjugated with dendrimers are slowly released, accumulate in tumors and have lower toxicity. Despite many advantages dendrimerswhich possess cationic groups on the surface are very cytotoxic and hemolytic. Because of that the modifications of surface groups are done but they influence on the carriers efficiency. In this work poly (propylene imine) (PPI) dendrimers of generation5 (G5) with primary amino surface groups were partially (open shell glycodendrimers - OS) or completely (dense shell glycodendrimers - DS) modified with maltose residues. As a model membranes two kinds of 100 nm diameter liposomes were used to researchdifferences in interactions between neutral (DMPC) and negatively charged (DMPC/DMPG) bilayers. Interactions were studied by fluorescence spectroscopy method. In conclusion, both OS and DS PPI G5 dendrimers show interactions with liposome
Czech name
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Czech description
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Project
<a href="/en/project/EE2.3.30.0062" target="_blank" >EE2.3.30.0062: Chance for young researchers at the University of J. E. Purkyně</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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