Effect of Simvastatin, Coenzyme Q10, Resveratrol, Acetylcysteine and Acetylcarnitine on Mitochondrial Respiration

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F16%3A43887662" target="_blank" >RIV/44555601:13440/16:43887662 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10327271

Result on the web

<a href="http://fb.cuni.cz/file/5803/fb2016a0007.pdf" target="_blank" >http://fb.cuni.cz/file/5803/fb2016a0007.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effect of Simvastatin, Coenzyme Q10, Resveratrol, Acetylcysteine and Acetylcarnitine on Mitochondrial Respiration

Original language description

Some therapeutic and/or adverse effects of drugs may be related to their effects on mitochondrial function. Effects of simvastatin, resveratrol, coenzyme Q10, acetylcysteine, and acetylcarnitine on Complex I-, Complex II-, or Complex IV-linked respiratory rate were determined in isolated brain mitochondria. The protective effects of these biologically active compounds on calcium induced decrease of the respiratory rate were also studied. We observed significant inhibitory effect of simvastatin on mitochondrial respiration (IC50 = 24.0 ?M for Complex I-linked respiration, IC50 = 31.3 ?M for Complex II-linked respiration, and IC50 = 42.9 ?M for Complex IV-linked respiration); the inhibitory effect of resveratrol was found at very high concentrations (IC50 =162 ?M for Complex I-linked respiration, IC50 = 564 ?M for Complex II-linked respiration, and IC50 = 1454 ?M for Complex IV-linked respiration). Concentrations necessary for effective simvastatin- or resveratrol-induced inhibition of mitochondrial respiration were found much higher than concentrations achieved under standard dosing of these drugs. Acetylcysteine and acetylcarnitine did not affect the oxygen consumption rate of mitochondria. Coenzyme Q10 induced an increase of Complex I-linked respiration. The increase of free calcium ions induced a partial inhibition of the Complex I+II-linked mitochondrial respiration, and all tested drugs counteracted this inhibition. None of tested drugs showed mitochondrial toxicity (characterized by respiratory rate inhibition) at drug concentrations achieved at therapeutic drug intake. Resveratrol, simvastatin, and acetylcarnitine have larges neuroprotective potential (characterized by protective effects against calcium-induced reduction of the respiratory rate).

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

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Project

<a href="/en/project/NV15-28967A" target="_blank" >NV15-28967A: Modulators of mitochondrial enzymes for treatment of neurodegenerative disorders</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica

ISSN

0015-5500

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

14

Pages from-to

53-66

UT code for WoS article

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EID of the result in the Scopus database

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