Antiviral mechanism of polyanionic carbosilane dendrimers against HIV-1

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F16%3A43887667" target="_blank" >RIV/44555601:13440/16:43887667 - isvavai.cz</a>

Result on the web

<a href="https://www.dovepress.com/antiviral-mechanism-of-polyanionic-carbosilane-dendrimers-against-hiv--peer-reviewed-fulltext-article-IJN" target="_blank" >https://www.dovepress.com/antiviral-mechanism-of-polyanionic-carbosilane-dendrimers-against-hiv--peer-reviewed-fulltext-article-IJN</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/IJN.S96352" target="_blank" >10.2147/IJN.S96352</a>

Result language

angličtina

Original language name

Antiviral mechanism of polyanionic carbosilane dendrimers against HIV-1

Original language description

Nanotechnology-derived platforms, such as dendrimers, are very attractive in several biological applications. In the case of human immunodeficiency virus (HIV) infection, polyanionic carbosilane dendrimers have shown great potential as antiviral agents in the development of novel microbicides to prevent the sexual transmission of HIV-1. In this work, we studied the mechanism of two sulfated and naphthylsulfonated functionalized carbosilane dendrimers, G3-S16 and G2-NF16. They are able to inhibit viral infection at fusion and thus at the entry step. Both compounds impede the binding of viral particles to target cell surface and membrane fusion through the blockage of gp120-CD4 interaction. In addition, and for the first time, we demonstrate that dendrimers can inhibit cell-to-cell HIV transmission and difficult infectious synapse formation. Thus, carbosilane dendrimers' mode of action is a multifactorial process targeting several proteins from viral envelope and from host cells that could block HIV infection at different stages during the first step of infection.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Nanotechnology

ISSN

1475-7435

e-ISSN

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Volume of the periodical

2016

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

1281-1294

UT code for WoS article

000373327100001

EID of the result in the Scopus database

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