Filtration of DNA Nucleotide Gene Expression Profiles in the Systems of Biological Objects Clustering

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F16%3A43887686" target="_blank" >RIV/44555601:13440/16:43887686 - isvavai.cz</a>

Result on the web

<a href="https://www.scipress.com/IFSL.8.1" target="_blank" >https://www.scipress.com/IFSL.8.1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.18052/www.scipress.com/IFSL.8.1" target="_blank" >10.18052/www.scipress.com/IFSL.8.1</a>

Result language

angličtina

Original language name

Filtration of DNA Nucleotide Gene Expression Profiles in the Systems of Biological Objects Clustering

Original language description

Researches on an optimization of the filtration process of DNA nucleotides gene expression profiles are presented in the article. The data of lung cancer patients E-GEOD-68571 of Array Express database were used as experimental data. Filtration was carried out under the terms of the expression detecting of corresponding gene, herewith the variance of gene expression, the absolute value of expression and the Shannon entropy were used as criteria. The value of thresholding coefficient was estimated on the basis of average proximity measure of objects within the homogenous group and between groups. 470 columns were removed in the process of data filtering, and the matrix dimension of the test data has changed from (96x7129) to (96x6659). Estimation of the quality of information processing was performed by the comparative analysis of the clustering results of processed and unprocessed data.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Frontier Science Letters

ISSN

2349-4484

e-ISSN

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Volume of the periodical

2016

Issue of the periodical within the volume

8

Country of publishing house

CH - SWITZERLAND

Number of pages

8

Pages from-to

1-8

UT code for WoS article

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EID of the result in the Scopus database

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