Exploratory analysis of neuroblastoma data genes expressions based on bioconductor package tools
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F19%3A43894818" target="_blank" >RIV/44555601:13440/19:43894818 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Exploratory analysis of neuroblastoma data genes expressions based on bioconductor package tools
Original language description
The technique of gene expression profiles exploratory analysis on the basis of the use of Bioconductor package tools is presented in the paper. Applying this method allows forming the matrix of genes expression for further gene regulatory networks reconstruction and simulation of the obtained model. The gene expression profiles of human neuroblastoma cells obtained using high throughput RNA-sequencing technique have been used as the experimental data to evaluate the effectiveness of the appropriate step implementation. Applying of the proposed technique involved removing low expressed genes at the first step. The number of genes was reduced from 53186 to 7435 at this step. The filtered gene expression profiles normalizing was considered at the next step. The quality of data normalizing was evaluated by both various graphic tools and using quantitative criterion, which was calculated based on the cluster analysis for the samples which were previously distributed into clusters.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
CEUR Workshop Proceedings
ISBN
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ISSN
1613-0073
e-ISSN
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Number of pages
12
Pages from-to
268-279
Publisher name
CEUR-WS
Place of publication
Lviv
Event location
Lviv
Event date
Nov 11, 2019
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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