Endothelial glycocalyx in acute care surgery - what anaesthesiologists need to know for clinical practice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13450%2F19%3A43895411" target="_blank" >RIV/44555601:13450/19:43895411 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/19:10402193 RIV/00216208:11150/19:10402193 RIV/00179906:_____/19:10402193 RIV/00669806:_____/19:10402193
Result on the web
<a href="https://bmcanesthesiol.biomedcentral.com/track/pdf/10.1186/s12871-019-0896-2" target="_blank" >https://bmcanesthesiol.biomedcentral.com/track/pdf/10.1186/s12871-019-0896-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12871-019-0896-2" target="_blank" >10.1186/s12871-019-0896-2</a>

Result language
angličtina
Original language name
Endothelial glycocalyx in acute care surgery - what anaesthesiologists need to know for clinical practice
Original language description
The endothelial glycocalyx (EG) is the thin sugar-based lining on the apical surface of endothelial cells. It has been linked to the physiological functioning of the microcirculation and has been found to be damaged in critical illness and after acute care surgery. This review aims to describe the role of EG in severely injured patients undergoing surgery, discuss specific situations (e.G. major trauma, hemorrhagic shock, trauma induced coagulopathy) as well as specific interventions commonly applied in these patients (e.g. fluid therapy, transfusion) and specific drugs related to perioperative medicine with regard to their impact on EG. EG in acute care surgery is exposed to damage due to tissue trauma, inflammation, oxidative stress and inadequate fluid therapy. Even though some interventions (transfusion of plasma, human serum albumin, hydrocortisone, sevoflurane) are described as potentially EG protective there is still no specific treatment for EG protection and recovery in clinical medicine. The most important principle to be adopted in routine clinical practice at present is to acknowledge the fragile structure of the EG and avoid further damage which is potentially related to worsened clinical outcome.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30223 - Anaesthesiology

Project
<a href="/en/project/NV15-31881A" target="_blank" >NV15-31881A: Alterations of glycocalyx in critical illness and during major surgery and approaches for glycocalyx protection</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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