Endovascular treatment for acute ischemic stroke in patients with tandem lesion in the anterior circulation: analysis from the METRICS study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13450%2F23%3A43898321" target="_blank" >RIV/44555601:13450/23:43898321 - isvavai.cz</a>

Alternative codes found

RIV/27283933:_____/22:00011138 RIV/00216224:14110/23:00130230 RIV/61988987:17110/22:A2402JK8 RIV/00216208:11130/23:10446142 and 13 more

Result on the web

<a href="https://jnis.bmj.com/content/15/e1/e123" target="_blank" >https://jnis.bmj.com/content/15/e1/e123</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/jnis-2022-019176" target="_blank" >10.1136/jnis-2022-019176</a>

Result language

angličtina

Original language name

Endovascular treatment for acute ischemic stroke in patients with tandem lesion in the anterior circulation: analysis from the METRICS study

Original language description

Background Acute ischemic stroke (AIS) due to anterior circulation tandem lesion (TL) remains a technical and clinical challenge for endovascular treatment (EVT). Conflicting results from observational studies and missing evidence from the randomized trials led us to report a recent real-world multicenter clinical experience and evaluate possible predictors of good outcome after EVT.Methods We analyzed all AIS patients with TL enrolled in the prospective national study METRICS (Mechanical Thrombectomy Quality Indicators Study in Czech Stroke Centers). A good 3-month clinical outcome was scored as 0?2 points in modified Rankin Scale (mRS), achieved recanalization using the Thrombolysis In Cerebral Infarction (TICI) scale and symptomatic intracerebral hemorrhage (sICH) according to the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST) criteria.Results Of 1178 patients enrolled in METRICS, 194 (19.2%) (59.8% males, mean age 68.7?11.5 years) were treated for TL. They did not differ in mRS 0?2 (48.7% vs 46.7%; p=0.616), mortality (17.3% vs 22.7%; p=0.103) and sICH (4.7% vs 5.1%; p=0.809) from those with single occlusion (SO). More TL patients with prior intravenous thrombolysis (IVT) reached TICI 3 (70.3% vs 50.8%; p=0.012) and mRS 0?2 (55.4% vs 34.4%; p=0.007) than those without IVT. No difference was found in the rate of sICH (6.2% vs 1.6%; p=0.276). Multivariate logistic regression analysis showed prior IVT as a predictor of mRS 0?2 after adjustment for potential confounders (OR 3.818, 95%?CI 1.614 to 9.030, p=0.002).Conclusion Patients with TL did not differ from those with SO in outcomes after EVT. TL patients with prior IVT had more complete recanalization and mRS 0?2 and IVT was found to be a predictor of good outcome after EVT.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of NeuroInterventional Surgery

ISSN

1759-8478

e-ISSN

1759-8486

Volume of the periodical

15

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

123-128

UT code for WoS article

000844719700001

EID of the result in the Scopus database

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