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Male fertility restored by transplanting primordial germ cells into testes: A new way towards efficient transgenesis in chicken

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46356606%3A_____%2F17%3AN0000004" target="_blank" >RIV/46356606:_____/17:N0000004 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378050:_____/17:00487318

  • Result on the web

    <a href="https://www.nature.com/articles/s41598-017-14475-w" target="_blank" >https://www.nature.com/articles/s41598-017-14475-w</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/s41598-017-14475-w" target="_blank" >10.1038/s41598-017-14475-w</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Male fertility restored by transplanting primordial germ cells into testes: A new way towards efficient transgenesis in chicken

  • Original language description

    The ongoing progress in primordial germ cell derivation and cultivation is opening new ways in reproductive biotechnology. This study tested whether functional sperm cells can be matured from genetically manipulated primordial germ cells after transplantation in adult testes and used to restore fertility. We show that spermatogenesis can be restored after mCherry-expressing or GFP-expressing primordial germ cells are transplantated into the testes of sterilized G(0) roosters and that mCherry-positive or GFP-positive non-chimeric transgenic G(1) offspring can be efficiently produced. Compared with the existing approaches to primordial germ cell replacement, this new technique eliminates the germ line chimerism of G(0) roosters and is, therefore, faster, more efficient and requires fewer animals. Furthermore, this is the only animal model, where the fate of primordial germ cells in infertile recipients can be studied.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10604 - Reproductive biology (medical aspects to be 3)

Result continuities

  • Project

    <a href="/en/project/GA15-23993S" target="_blank" >GA15-23993S: Gene targeting in chicken and the resistance to newly emerging retroviruses</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Scientific Reports

  • ISSN

    2045-2322

  • e-ISSN

    2045-2322

  • Volume of the periodical

    7

  • Issue of the periodical within the volume

    14246

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    9

  • Pages from-to

  • UT code for WoS article

    000413907000069

  • EID of the result in the Scopus database

    2-s2.0-85032461218