Influence of Silica Shell on Toxicity of Manganese Perovskite Magnetic Nanoparticles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46504711%3A_____%2F14%3A%230000425" target="_blank" >RIV/46504711:_____/14:#0000425 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Influence of Silica Shell on Toxicity of Manganese Perovskite Magnetic Nanoparticles
Original language description
Complex magnetic oxides as core materials are interesting because their magnetic properties can be regulated by various ways very well. These magnetic nanoparticles can be interesting for application in biomedicine as a contrast agent for magnetic resonance imaging or as a colloidal mediator for destruction of cancer cells by magnetic fluid hyperthermia. Magnetic nanoparticles of manganite La0.75Sr0.25MnO3 were synthesized by sol - gel method. Prepared magnetic cores had to be converted into a stable and non toxic suspension to allow their administration either by intratumoural or intravenous way. For this purpose coating by silica shell was chosen, which provides stabilization by electrostatic repulsion. Silica shell was formed by polycondensation reactions of tetraethoxysilane hydrolytic products. Thickness of silica shell can significantly influence magnetic cores toxicity and quality of the suspension.
Czech name
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Czech description
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Project
<a href="/en/project/FR-TI3%2F521" target="_blank" >FR-TI3/521: Technology of new magnetic nanoparticles for diagnostics and therapy in oncology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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