Three-year study of markers of oxidative stress in exhaled breath condensate in workers producing nanocomposites, extended by plasma and urine analysis in last two years

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24210%2F20%3A00008863" target="_blank" >RIV/46747885:24210/20:00008863 - isvavai.cz</a>

Alternative codes found

RIV/67985858:_____/20:00535687 RIV/68378041:_____/20:00535687 RIV/61388955:_____/20:00535687 RIV/00064165:_____/20:10419737 and 2 more

Result on the web

<a href="https://www.mdpi.com/2079-4991/10/12/2440/pdf" target="_blank" >https://www.mdpi.com/2079-4991/10/12/2440/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/nano10122440" target="_blank" >10.3390/nano10122440</a>

Result language

angličtina

Original language name

Three-year study of markers of oxidative stress in exhaled breath condensate in workers producing nanocomposites, extended by plasma and urine analysis in last two years

Original language description

Human data concerning exposure to nanoparticles are very limited, and biomarkers for monitoring exposure are urgently needed. In a follow-up of a 2016 study in a nanocomposites plant, in which only exhaled breath condensate (EBC) was examined, eight markers of oxidative stress were analyzed in three bodily fluids, i.e., EBC, plasma and urine, in both pre-shift and post-shift samples in 2017 and 2018. Aerosol exposures were monitored. Mass concentration in 2017 was 0.351 mg/m3 during machining, and 0.179 and 0.217 mg/m3 during machining and welding, respectively, in 2018. In number concentrations, nanoparticles formed 96%, 90% and 59%, respectively. In both years, pre-shift elevations of 50.0% in EBC, 37.5% in plasma and 6.25% in urine biomarkers were observed. Post-shift elevation reached 62.5% in EBC, 68.8% in plasma and 18.8% in urine samples. The same trend was observed in all biological fluids. Individual factors were responsible for the elevation of control subjects’ afternoon vs. morning markers in 2018; all were significantly lower compared to those of workers. Malondialdehyde levels were always acutely shifted, and 8-hydroxy-2-deoxyguanosine levels best showed chronic exposure effect. EBC and plasma analysis appear to be the ideal fluids for bio-monitoring of oxidative stress arising from engineered nanomaterials. Potential late effects need to be targeted and prevented, as there is a similarity of EBC findings in patients with silicosis and asbestosis.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

21001 - Nano-materials (production and properties)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nanomaterials

ISSN

2079-4991

e-ISSN

—

Volume of the periodical

10

Issue of the periodical within the volume

12

Country of publishing house

CH - SWITZERLAND

Number of pages

25

Pages from-to

—

UT code for WoS article

000602622000001

EID of the result in the Scopus database

2-s2.0-85097542423