Nanofibrous patches for cardiac drug delivery

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24220%2F16%3A00008524" target="_blank" >RIV/46747885:24220/16:00008524 - isvavai.cz</a>

Alternative codes found

RIV/46747885:24620/16:00008524

Result on the web

<a href="https://www.confer.cz/nanocon/2016/read/509-nanofibrous-patches-for-cardiac-drug-delivery.pdf" target="_blank" >https://www.confer.cz/nanocon/2016/read/509-nanofibrous-patches-for-cardiac-drug-delivery.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Nanofibrous patches for cardiac drug delivery

Original language description

Potential application of nanofibers in drug delivery has attracted a huge attention recently highlighting their properties including increased surface reactivity, high specific surface and improved drug bioavailability. Cardiac regenerative therapy, whereby pro-regenerative cells, drugs or growth factors are administered to myocardium has demonstrated significant potential in post-operative therapy. One of the main conditions applied on drug delivery system materials are cardiac biocompatibility, tolerability, treatment efficacy. Our objective in this study was to develop a nanofibrous patch with a short degradation time for cardiac drug delivery and evaluate its properties relevant for the application site. Silk fibroin based nanofibres were manufactured from Bombyx mori raw cocoons by degum procedure, ionic liquid dissolution and subsequent needle-less electrospinning. The electrospun nanofibres were crosslinked by alcohol dehydration. Stabilized and unstabilized nanofibrous patches were characterized in terms of morphology, chemical composition and degradation kinetics. The main objective was focused on cardiac cytotoxic effect of nanofibres and its evaluation on H9C2 rat myoblastic cell line.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Project

<a href="/en/project/LO1201" target="_blank" >LO1201: DEVELOPMENT OF THE INSTITUTE FOR NANOMATERIALS, ADVANCED TECHNOLOGIES AND INNOVATION</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application

ISBN

978-808729471-0

ISSN

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e-ISSN

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Number of pages

6

Pages from-to

478-483

Publisher name

TANGER Ltd.

Place of publication

Brno

Event location

Brno

Event date

Jan 1, 2016

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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