Crayfish Hemocyanin Promotes the Proliferation and Osteogenic Differentiation of Human Mesenchymal Stem Cells on Chitin Scaffolds
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24220%2F20%3A00008522" target="_blank" >RIV/46747885:24220/20:00008522 - isvavai.cz</a>
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/31755232/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/31755232/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jbm.a.36849" target="_blank" >10.1002/jbm.a.36849</a>
Alternative languages
Result language
angličtina
Original language name
Crayfish Hemocyanin Promotes the Proliferation and Osteogenic Differentiation of Human Mesenchymal Stem Cells on Chitin Scaffolds
Original language description
In this study, we developed and investigated hemocyanin-modified chitin- calcium-mineral complexes as composite materials for bone regeneration. In particular the focus was put on their ability to bind or release calcium ions and thus influence osteoblastogenesis in vitro. Incorporation of crustacean (crayfish) hemocyanin in these scaffolds was performed, since it plays a significant role in intermittent calcium mineral storage and release. Surprisingly, even hemocyanin alone exhibits enhanced proliferation and osteogenic differentiation. Furthermore, the hemocyanin-modification significantly increased human mesenchymal stem cell adhesion, proliferation and osteogenic differentiation. Under addition of CaCO3 to the scaffolds the hemocyanin-modification led to highest proliferation of hMSC.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biomedical Materials Research - Part A
ISSN
1549-3296
e-ISSN
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Volume of the periodical
108
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
694-708
UT code for WoS article
000501192900001
EID of the result in the Scopus database
2-s2.0-85076357517