Iron-doped calcium phytate nanoparticles as a bio-responsive contrast agent in H-1/P-31 magnetic resonance imaging

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24220%2F22%3A00010973" target="_blank" >RIV/46747885:24220/22:00010973 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/s41598-022-06125-7" target="_blank" >https://www.nature.com/articles/s41598-022-06125-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-022-06125-7" target="_blank" >10.1038/s41598-022-06125-7</a>

Result language

angličtina

Original language name

Iron-doped calcium phytate nanoparticles as a bio-responsive contrast agent in H-1/P-31 magnetic resonance imaging

Original language description

We present the MR properties of a novel bio-responsive phosphorus probe doped with iron for dual proton and phosphorus magnetic resonance imaging (H-1/P-31-MRI), which provide simultaneously complementary information. The probes consist of non-toxic biodegradable calcium phytate (CaIP6) nanoparticles doped with different amounts of cleavable paramagnetic Fe3 ions. Phosphorus atoms in the phytate structure delivered an efficient P-31-MR signal, with iron ions altering MR contrast for both H-1 and P-31-MR. The coordinated paramagnetic Fe3 ions broadened the P-31-MR signal spectral line due to the short T-2 relaxation time, resulting in more hypointense signal. However, when Fe3 was decomplexed from the probe, relaxation times were prolonged. As a result of iron release, intensity of H-1-MR, as well as the P-31-MR signal increase. These H-1 and P-31-MR dual signals triggered by iron decomplexation may have been attributable to biochemical changes in the environment with strong iron chelators, such as bacterial siderophore (deferoxamine). Analysing MR signal alternations as a proof-of-principle on a phantom at a 4.7 T magnetic field, we found that iron presence influenced H-1 and P-31 signals and signal recovery via iron chelation using deferoxamine.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10700 - Other natural sciences

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

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Volume of the periodical

12

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

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UT code for WoS article

000756832600024

EID of the result in the Scopus database

2-s2.0-85124286306