New Aligned Microfibers for Tissue Engineering

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F15%3A00000649" target="_blank" >RIV/46747885:24410/15:00000649 - isvavai.cz</a>

Alternative codes found

RIV/46747885:24620/15:00000649

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

New Aligned Microfibers for Tissue Engineering

Original language description

The present work deals with preparation and subsequent modification of aligned polycaprolactone microfibers made by new semiautomatic drawing technique. This advanced scaffold for tissue engineering combines 3D architecture, large surface area-to-volume ratio, alterable conductivity which closely imitates native extracellular matrix and actively modulating cell functions. New synthetic approach has been chosen for derivatization of aligned polymer fibers, which lack any surface functional groups for immobilization of biomolecules, grow factors or specific amino acid sequences. To overcome this drawback the thin conductive polypyrrole layer was applied on the polycaprolactone fibers by chemical oxidative polymerization from the solution. Thus, in the one simple synthetic step we can modify original fibers with various functional groups presented in the β-position of the pyrrole. Our future goal is to functionalize microfibrous surface with cyclodextrin units using highly efficient copper free click reaction. Finally we gain an aligned microfibrous scaffold covered by immobilized cyclodextrin macrocycles that allow inclusion of proteins during cell cultivation. These nonbonding interactions are relatively weak but the cumulative effect makes them efficient in the complexation of various neutral or ionic molecules. Moreover better environment for cell adhesion and proliferation is being provided.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Nanocon 2015: 7th International Conference on Nanomaterials - Research and Application

ISBN

978-80-87294-63-5

ISSN

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e-ISSN

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Number of pages

5

Pages from-to

399-403

Publisher name

TANGER Ltd.

Place of publication

Ostrava

Event location

Brno

Event date

Jan 1, 2015

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000374708800070