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INCORPORATION NITRIC OXIDE DONORS INTO FIBROUS MATERIAL INTENDED FOR VASCULAR GRAFTS

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F16%3A00003864" target="_blank" >RIV/46747885:24410/16:00003864 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.nanocon.eu/cz/" target="_blank" >http://www.nanocon.eu/cz/</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    INCORPORATION NITRIC OXIDE DONORS INTO FIBROUS MATERIAL INTENDED FOR VASCULAR GRAFTS

  • Original language description

    Nitric Oxide (NO) is a very promising molecule suitable for applications in cardiovascular system. NO has many beneficial effects such as anti-thrombogenic and anti-inflammatory properties together with endothelial cell support. Presented work was focused on functionalization of electrospun biodegradable materials by nitric oxide donors for further usage as vascular grafts. Firstly, the optimization of biodegradable nanofibrous layers was carried out. Fibrous sheets were produced from the aliphatic polyester polycaprolactone (PCL) that was blended with nitric oxide donor S-nitrosoacetyl N-penicillamine (SNAPs) in various concentrations of 0.2 wt % and 0.4 wt%. Subsequently, prepared layers with and without NO donors were tested in vitro using endothelial cells and its effect was compared. Nitric oxide release from functionalized layers was detected by colorimetric Griess assay after 1, 2 and 3 days of incubation. Moreover, sterilization methods and their impact for NO release was monitored.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    FA - Cardiovascular diseases including cardio-surgery

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NV15-29241A" target="_blank" >NV15-29241A: Nanofibrous Biodegradable Small-Diameter Vascular Bypass Graft</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application

  • ISBN

    978-80-87294-71-0

  • ISSN

  • e-ISSN

  • Number of pages

    5

  • Pages from-to

    424-428

  • Publisher name

    Tanger Ltd.

  • Place of publication

    Ostrava

  • Event location

    Brno

  • Event date

    Jan 1, 2016

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article