INCORPORATION NITRIC OXIDE DONORS INTO FIBROUS MATERIAL INTENDED FOR VASCULAR GRAFTS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F16%3A00003864" target="_blank" >RIV/46747885:24410/16:00003864 - isvavai.cz</a>
Result on the web
<a href="http://www.nanocon.eu/cz/" target="_blank" >http://www.nanocon.eu/cz/</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
INCORPORATION NITRIC OXIDE DONORS INTO FIBROUS MATERIAL INTENDED FOR VASCULAR GRAFTS
Original language description
Nitric Oxide (NO) is a very promising molecule suitable for applications in cardiovascular system. NO has many beneficial effects such as anti-thrombogenic and anti-inflammatory properties together with endothelial cell support. Presented work was focused on functionalization of electrospun biodegradable materials by nitric oxide donors for further usage as vascular grafts. Firstly, the optimization of biodegradable nanofibrous layers was carried out. Fibrous sheets were produced from the aliphatic polyester polycaprolactone (PCL) that was blended with nitric oxide donor S-nitrosoacetyl N-penicillamine (SNAPs) in various concentrations of 0.2 wt % and 0.4 wt%. Subsequently, prepared layers with and without NO donors were tested in vitro using endothelial cells and its effect was compared. Nitric oxide release from functionalized layers was detected by colorimetric Griess assay after 1, 2 and 3 days of incubation. Moreover, sterilization methods and their impact for NO release was monitored.
Czech name
—
Czech description
—
Classification
Type
D - Article in proceedings
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/NV15-29241A" target="_blank" >NV15-29241A: Nanofibrous Biodegradable Small-Diameter Vascular Bypass Graft</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application
ISBN
978-80-87294-71-0
ISSN
—
e-ISSN
—
Number of pages
5
Pages from-to
424-428
Publisher name
Tanger Ltd.
Place of publication
Ostrava
Event location
Brno
Event date
Jan 1, 2016
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
—